The use of chemotherapy in patients with gliomas: Patterns of care in Victoria from 1998-2000
The use of chemotherapy in patients with gliomas: Patterns of care in Victoria from 1998-2000
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DOI：
10.1016/j.jocn.2007.04.001
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发表时间：
2008-04-01
影响因子：
2
通讯作者：
Giles, Graham G.
中科院分区：
文献类型：
--
作者：
Cher, Lawrence;Rosenthal, Mark A.;Giles, Graham G.
化疗在神经胶质瘤的治疗中发挥着越来越重要的作用。特别是，化疗在复发性高级别胶质瘤和新诊断的多形性胶质母细胞瘤患者中提供生存和生活质量益处。我们以前曾报道过1998-2000年期间维多利亚州828例诊断为神经胶质瘤的患者的护理模式的细节。我们观察到250例患者（30%）在疾病的某个阶段接受了化疗，包括新辅助治疗、辅助治疗和复发性临床治疗。在所使用的药物及其时间安排方面存在显著差异。60岁以上的患者中，只有15%的患者在任何时候接受化疗。8%的患者参加了化疗临床试验。随着神经胶质瘤化疗成为根深蒂固的护理标准，这项调查将提供对未来护理模式变化的见解，并指出这些肿瘤管理的需求领域。(C)2007年由Elsevier Ltd.出版
Chemotherapy has an increasing role in the management of gliomas. In particular, chemotherapy provides survival and quality of life benefits in the setting of recurrent high-grade gliomas and in patients with newly diagnosed glioblastoma multiforme. We have previously reported details on patterns of care regarding 828 patients diagnosed with a glioma in the state of Victoria for the period 1998-2000. We observed that 250 patients (30%) received chemotherapy at some stage of their illness, including neo-adjuvant, adjuvant and recurrent clinical settings. There was significant variation in the agents used and their scheduling. Chemotherapy was given at any time in only 15% of patients aged over 60 years. Eight percent of patients were enrolled on a chemotherapy clinical trial. As chemotherapy for gliomas becomes entrenched as the standard of care, this survey will provide an insight into changing patterns of care for the future and points to areas of need in management of these tumours. (C) 2007 Published by Elsevier Ltd.