Incidence of psoriasis in children: A population-based study
Incidence of psoriasis in children: A population-based study
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DOI：
10.1016/j.jaad.2009.07.029
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发表时间：
2010-06-01
影响因子：
13.8
通讯作者：
Kremers, Hilal Maradit
中科院分区：
文献类型：
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作者：
Tollefson, Megha M.;Crowson, Cynthia S.;Kremers, Hilal Maradit
背景：虽然银屑病在发病年龄上被认为是双峰型的，但目前还没有关于银屑病在儿童中的发病率的研究。目的：本研究的目的是确定银屑病在儿童中的发病率。对每个儿童的完整医疗记录进行审查，并通过皮肤科医生在医疗记录中的确认性诊断或皮肤科医生的医疗记录审查来确认银屑病诊断。计算了年龄和性别的发病率，并根据2000名美国白人人口的年龄和性别进行了调整。结果：经年龄和性别调整的儿童银屑病年发病率为40.8/10万(95%可信区间：36.6-45.1)。当银屑病的诊断仅限于病历中经皮肤科医生确认的受试者时，发病率为33.2/10万(95%可信区间：29.3-37.0)。儿童牛皮癣的发病率随着时间的推移显著增加，从1970年到1974年的29.6/10万，到1995年到1999年的62.7/10万(P<；.001)。慢性斑块型银屑病是最常见的银屑病类型(73.7%)，最常见的受累部位是四肢(59.9%)和头皮(46.8%)。限制：研究人群以中西部北部白人为主。结论：儿童银屑病的发病率随着年龄的增长而增加。发病率没有明显的双峰。近年来，儿童银屑病的发病率在男孩和女孩中都有所增加。(J am Acad Dermatol 2010；62：979-87。)
Background: Although psoriasis is considered to have a dual peak in age of onset, currently no studies exist regarding the incidence of psoriasis in children.Objective: The objective of this study was to determine the incidence of psoriasis in childhood.Methods: A population-based incidence cohort of patients aged younger than 18 years first given the diagnosis of psoriasis between January 1, 1970, and December 31, 1999, was assembled. The complete medical record of each child was reviewed and psoriasis diagnosis was validated by a confirmatory diagnosis in the medical record by a dermatologist or medical record review by a dermatologist. Age- and sex-specific incidence rates were calculated and were age and sex adjusted to 2000 US white population.Results: The overall age- and sex-adjusted annual incidence of pediatric psoriasis was 40.8 per 100,000 (95% confidence interval: 36.6-45.1). When psoriasis diagnosis was restricted to dermatologist-confirmed subjects in the medical record, the incidence was 33.2 per 100,000 (95% confidence interval: 29.3-37.0). Incidence of psoriasis in children increased significantly over time from 29.6 per 100,000 in 1970 through 1974 to 62.7 per 100,000 in 1995 through 1999 (P < .001). Chronic plaque psoriasis was the most common type (73.7%), and the most commonly involved sites were the extremities (59.9%) and the scalp (46.8%).Limitations: The population studied was a mostly white population in the upper Midwest.Conclusion: The incidence of pediatric psoriasis increases with increasing age. There is no apparent dual peak in incidence. The incidence of pediatric psoriasis increased in recent years in both boys and girls. (J Am Acad Dermatol 2010;62:979-87.)