A brush stimulator for functional brain imaging
A brush stimulator for functional brain imaging
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DOI：
10.1016/j.clinph.2007.08.024
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发表时间：
2007-12-01
影响因子：
4.7
通讯作者：
Hari, R.
中科院分区：
文献类型：
--
作者：
Jousmaki, V.;Nishitani, N.;Hari, R.
目的：描述一种新的非磁性手持装置，用于刺激皮肤的各个部位，并评估其在脑磁图（MEG）记录中的表现。方法：设备的手持部分由光纤束组成，形成一个小刷子。一半的纤维发出调制的红光，另一半检测来自皮肤的反射光，从而通过反射来检测刷与皮肤的接触。结果：轻拍手背桡神经支配区，10名被试均能产生明显的反应，主要偏转在刺激后40-70 ms达到峰值。在平均试验次数较多的情况下，最早的反应在轻触左手背后27-28毫秒达到峰值。脑磁图信号的来源分析表明，神经源位于初级体感皮层，面部和手部的体感神经源顺序清晰。结论：该装置在MEG和功能磁共振成像实验中似乎都是可行的，可以通过类似现实生活的刺激来解决人类体感系统的功能解剖问题。意义：具有选择性刺激的无磁无伪触觉刺激器为研究人体机械感受器系统的实验设计提供了新的可能性。(c) 2007年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: To describe a novel non-magnetic hand-held device to stimulate various parts of the skin and to evaluate its performance in magnetoencephalographic (MEG) recordings.Methods: The hand-held part of the device consists of an optic fiber bundle that forms a small brush. Half of the fibers emit modulated red light and the other half detect the reflected light from the skin so that the brush-to-skin contact is detected by means of reflectance.Results: Light tapping of the back of the hand at the innervation area of the radial nerve elicited clear responses in all 10 subjects studied, with the main deflections peaking 40-70 ms after the stimulus. The earliest responses, obtained with a higher number of averaged trials, peaked 27-28 ms after the tap to the left hand dorsum. Source analysis of the MEG signals indicated neuronal sources at the primary somatosensory (SI) cortex, with a clear somatotopical order for face vs. hand.Conclusions: The device seems feasible for both MEG and functional magnetic resonance imaging experiments to address functional anatomy of the human somatosensory system with a real-life like stimulation.Significance: Non-magnetic and artefact-free tactile stimulator with a selective stimulus offers new possibilities for experimental designs to study the human mechanoreceptor system. (c) 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.