Activated T lymphocytes in the peripheral blood of patients with systemic lupus erythematosus induce B cells to produce immunoglobulin.
Activated T lymphocytes in the peripheral blood of patients with systemic lupus erythematosus induce B cells to produce immunoglobulin.
复制标题
DOI：
--
复制
发表时间：
1988-07
影响因子：
3.7
通讯作者：
Giorgio Inghirami;J. Simon;James E. Balow;G. Tsokos
中科院分区：
文献类型：
--
作者：
Giorgio Inghirami;J. Simon;James E. Balow;G. Tsokos
系统性红斑狼疮(SLE)是以多种T、B细胞异常为特征的疾病。本研究旨在用单、双免疫荧光法研究T细胞的细胞膜特性，探讨人类白细胞抗原-DR+T细胞在B细胞产生免疫球蛋白中的作用。结果显示：(A)证实SLE患者中存在比正常对照组更多的携带DR抗原的T细胞；(B)证实DR阳性细胞均匀分布于SLE患者淋巴细胞的辅助/诱导亚群和抑制/细胞毒性亚群中；(C)携带白细胞介素2(IL-2)受体的T细胞百分比没有升高；(D)证明DR阳性而不是DR阴性的T细胞在条件培养液中增殖；(E)证明DR阳性的T细胞提供了辅助因子，促进B细胞产生免疫球蛋白。我们认为SLE患者中携带DR抗原的T细胞在体内是有功能的，可能是导致B细胞过度活动的原因。
Systemic lupus erythematosus (SLE) is characterized by multiple T and B cell abnormalities. This study was designed to investigate the cell surface membrane characteristics of T cells by using single and double immunofluorescence and examine the role of HLA-DR+ T cells in the production of immunoglobulin by B cells. The results presented: (a) confirm the presence of a larger population of T-cells bearing DR antigens in patients with SLE than in normal controls, (b) demonstrate that DR positive cells are equally distributed in helper/inducer and suppressor/cytotoxic subsets of lymphocytes from patients with SLE, (c) show no elevation in the percentage of T cells bearing interleukin 2 (IL-2) receptors, (d) demonstrate that DR positive, but not DR negative T-cells, multiply in the presence of conditioned media and, (e) demonstrate that DR positive T cells provide helper factors which enhance the production of immunoglobulin by B cells. We propose that T-cells bearing DR antigens in patients with SLE are functional in vivo, and may be responsible for the B cell overactivity.