Thematic Review Series: Fat-Soluble Vitamins: Vitamin A Vitamin A and retinoid signaling: genomic and nongenomic effects
Thematic Review Series: Fat-Soluble Vitamins: Vitamin A Vitamin A and retinoid signaling: genomic and nongenomic effects
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发表时间：
2013
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通讯作者：
Ziad Al Tanoury;A. Piskunov;C. Rochette-Egly
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作者：
Ziad Al Tanoury;A. Piskunov;C. Rochette-Egly
维生素A或视黄醇可以说是人体中最多功能的维生素，因为它是从胚胎发育到成年所必需的。维生素A的多效性作用主要由一种活性代谢产物全反式维甲酸（atRA）发挥，它通过几个核受体家族（RAR、RXR和PPAR /）、多态性维甲酸（RA）反应元件和多种共调节因子调节一系列靶基因的表达。它还涉及核内和非转录效应，例如激酶级联的激活，其通过RA信号传导的几个作用物的磷酸化而整合到细胞核中。然而，维生素A本身最近被证明是有活性的，并且RAR存在于细胞溶质中以调节翻译和细胞可塑性。这些新概念扩大了维生素A和RA的生物学功能的范围。-Al Tanoury，Z.，A. Piskunov和C.罗切特-埃格利维生素A和类维生素A信号传导：基因组和非基因组效应。J. Lipid Res. 2013. 54：1761-1775。
Vitamin A or retinol is arguably the most multi- functional vitamin in the human body, as it is essential from embryogenesis to adulthood. The pleiotropic effects of vita- min A are exerted mainly by one active metabolite, all -trans retinoic acid (atRA), which regulates the expression of a bat- tery of target genes through several families of nuclear re- ceptors (RARs, RXRs, and PPAR / ), polymorphic retinoic acid (RA) response elements, and multiple coregulators. It also involves extranuclear and nontranscriptional effects, such as the activation of kinase cascades, which are inte- grated in the nucleus via the phosphorylation of several actors of RA signaling. However, vitamin A itself proved re- cently to be active and RARs to be present in the cytosol to regulate translation and cell plasticity. These new concepts expand the scope of the biologic functions of vitamin A and RA. —Al Tanoury, Z., A. Piskunov, and C. Rochette-Egly. Vitamin A and retinoid signaling: genomic and nongenomic effects. J. Lipid Res. 2013. 54: 1761-1775.