SYSTEMIC CHOLINERGIC AGENTS INDUCE SEIZURES AND BRAIN-DAMAGE IN LITHIUM-TREATED RATS
SYSTEMIC CHOLINERGIC AGENTS INDUCE SEIZURES AND BRAIN-DAMAGE IN LITHIUM-TREATED RATS
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DOI：
10.1126/science.6301005
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
SHERMAN, WR
中科院分区：
文献类型：
--
作者：
HONCHAR, MP;OLNEY, JW;SHERMAN, WR
用氯化锂治疗的大鼠给予匹罗卡品或毒豆碱可引起持续的边缘癫痫发作、大范围脑损伤和脑内d -肌醇-1-磷酸（磷酸肌醇的代谢物，参与膜受体功能的脂质）浓度升高。该综合征可通过阿托品预防。引起该综合征的毒豆碱剂量和血锂浓度与精神科化疗的适宜剂量和浓度相似。
Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain. The syndrome was preventable with atropine. The physostigmine doses and concentrations of blood lithium that caused the syndrome are similar to those considered appropriate for psychiatric chemotherapy.