The course of neuropsychiatric symptoms in dementia. Part II: relationships among behavioural sub-syndromes and the influence of clinical variables
The course of neuropsychiatric symptoms in dementia. Part II: relationships among behavioural sub-syndromes and the influence of clinical variables
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DOI：
10.1002/gps.1317
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发表时间：
2005-06-01
影响因子：
4
通讯作者：
Verhey, FRJ
中科院分区：
文献类型：
--
作者：
Aalten, P;de Vugt, ME;Verhey, FRJ
背景虽然有几项研究提到了神经精神症状之间的联系，但还没有前瞻性研究确定行为子综合征之间的相互关系。目的研究几个临床变量对神经精神症状病程的影响，并确定行为子综合征之间的相互关系。方法199例痴呆患者每6个月进行一次评估，持续两年。结果年龄、性别、社会经济状况与神经精神症状无相关性。更大的认知功能障碍与更严重的精神病有关，痴呆阶段影响总NPI问题的过程。大多数行为子综合征之间有很强的相互关系。亚证多动对精神病的发展有影响，但对精神病的发展无影响。也不是子综合征的情绪/冷漠的影响过程中的精神病。结论虽然不同的神经精神症状有自己的具体相关性，有很强的相互关系行为子综合征。这些数据对临床医生和痴呆症的神经精神症状的疾病分类学有意义。版权所有（c）2005年约翰威利父子有限公司。
Background Although several studies have mentioned associations between neuropsychiatric symptoms, there have been no prospective studies determining interrelations among behavioural sub-syndromes.Objectives To investigate the influence of several clinical variables on the course of neuropsychiatric symptoms, and to determine interrelationships between the behavioural sub-syndromes.Methods One hundred and ninety-nine patients with dementia were assessed every six months for two-years, using the Neuropsychiatric Inventory (NPI) to evaluate neuropsychiatric symptoms.Results Age, sex, and socioecononuc status were not associated with a specific neuropsychiatric symptom. Greater cognitive impairment was related to more severe psychosis, and dementia stage influenced the course of total NPI problems. There were strong interrelations among most behavioural sub-syndromes. The sub-syndrome hyperactivity was of influence on the development of psychosis, but not vice versa. Neither was the sub-syndrome mood/apathy of influence on the course of psychosis.Conclusions While different neuropsychiatric symptoms have their own specific correlates, there is a strong interrelationship between behavioural sub-syndromes. The data have implications for clinicians and the nosology of neuropsychiatric symptoms in dementia. Copyright (c) 2005 John Wiley & Sons, Ltd.