Relationship of personality disorders to the course of major depressive disorder in a nationally representative sample.
Relationship of personality disorders to the course of major depressive disorder in a nationally representative sample.
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DOI：
10.1176/appi.ajp.2010.10050695
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Hasin DS
中科院分区：
文献类型：
--
作者：
Skodol AE;Grilo CM;Keyes KM;Geier T;Grant BF;Hasin DS
本研究的目的是在一个全国性的代表性样本中检验特定人格障碍共病对重性抑郁障碍病程的影响。数据来自全国调查的1，996名参与者。在面对面访谈（2001-2002年）中基线符合重度抑郁障碍标准的参与者在三年后（2004-2005年）再次接受访谈，以确定持续性和复发性。预测因素包括所有DSM-IV人格障碍。控制变量包括人口统计学特征、其他轴I障碍、家族史和治疗史，以及先前确定的重度抑郁障碍病程的预测因子。15.1%的参与者患有持续性重度抑郁症，7.3%的缓解者复发。单变量分析表明，回避型、边缘型、表演型、偏执型、类偏执型和非典型型人格障碍都增加了持续性的风险。与轴I共病控制，但表演型人格障碍仍然显着。在所有其他人格障碍得到控制的情况下，边缘型和典型型仍然是重要的预测因子。在最后，多变量分析，控制年龄在发病的抑郁症，以前的发作次数，持续时间的当前发作，家族史，和治疗，边缘型人格障碍仍然是一个强大的预测重性抑郁症的持续性。无论是人格障碍还是其他临床变量都不能预测复发。在这个具有全国代表性的成年抑郁症患者样本中，边缘型人格障碍强烈预测了持久性，这一发现与最近的临床研究一致。人格精神病理学，特别是边缘型人格障碍，应在所有重度抑郁症患者中进行评估，在预后中考虑，并在治疗中解决。
The purpose of this study was to examine the effects of specific personality disorder co-morbidity on the course of major depressive disorder in a nationally-representative sample. Data were drawn from 1,996 participants in a national survey. Participants who met criteria for major depressive disorder at baseline in face-to-face interviews (2001–2002) were re-interviewed three years later (2004–2005) to determine persistence and recurrence. Predictors included all DSM-IV personality disorders. Control variables included demographic characteristics, other Axis I disorders, family and treatment histories, and previously established predictors of the course of major depressive disorder. 15.1% of participants had persistent major depressive disorder and 7.3% of those who remitted had a recurrence. Univariate analyses indicated that avoidant, borderline, histrionic, paranoid, schizoid, and schizotypal personality disorders all elevated the risk for persistence. With Axis I co-morbidity controlled, all but histrionic personality disorder remained significant. With all other personality disorders controlled, borderline and schizotypal remained significant predictors. In final, multivariate analyses that controlled for age at onset of major depressive disorder, number of previous episodes, duration of current episode, family history, and treatment, borderline personality disorder remained a robust predictor of major depressive disorder persistence. Neither personality disorders nor other clinical variables predicted recurrence. In this nationally-representative sample of adults with major depressive disorder, borderline personality disorder robustly predicted persistence, a finding that converges with recent clinical studies. Personality psychopathology, particularly borderline personality disorder, should be assessed in all patients with major depressive disorder, considered in prognosis, and addressed in treatment.
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DOI：
10.15288/jsa.1999.60.790
发表时间：
1999-11-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Canino, G;Bravo, M;Hasin, D
通讯作者：
Hasin, D
影响因子：
4.2
作者：
Heiman, Gary A.;Ogburn, Elizabeth;Hasin, Deborah
通讯作者：
Hasin, Deborah
影响因子：
5.3
作者：
Compton, WM;Conway, KP;Grant, BF
通讯作者：
Grant, BF
影响因子：
2.3
作者：
Gunderson, JG;Shea, MT;Keller, MB
通讯作者：
Keller, MB
影响因子：
3.8
作者：
Keyes, Katherine M.;Hatzenbuehler, Mark L.;Hasin, Deborah S.
通讯作者：
Hasin, Deborah S.