COMPARISON OF EUMELANOGENESIS AND PHEOMELANOGENESIS IN RETINAL AND FOLLICULAR MELANOCYTES - ROLE OF VESICULO-GLOBULAR BODIES IN MELANOSOME DIFFERENTIATION
COMPARISON OF EUMELANOGENESIS AND PHEOMELANOGENESIS IN RETINAL AND FOLLICULAR MELANOCYTES - ROLE OF VESICULO-GLOBULAR BODIES IN MELANOSOME DIFFERENTIATION
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DOI：
10.1111/1523-1747.ep12531650
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发表时间：
1979-01-01
影响因子：
6.5
通讯作者：
TAKEUCHI, T
中科院分区：
文献类型：
--
作者：
JIMBOW, K;OIKAWA, O;TAKEUCHI, T
黑素体中存在直径为40 nm的囊泡球状体。通过比较鸡和小鼠视网膜和滤泡黑素细胞中eu-和pheomelanogenesis的超微结构，研究了它们参与黑素体分化的模式。这些小体的数量和分布随黑素生成和组织的类型而显著不同。它们不受物理刺激或黑素细胞的胚胎起源的影响。黑素体的最早形式在真黑素生成和褐黑素生成中是相同的。囊泡小叶体参与黑素体成分的组织。在真黑素发生中，它们在羽毛中的数量多于视网膜和毛发。他们是最少的白色头发和粉红色的眼睛，那里的黑化被阻止。在黑素体发育期间，它们与黑素体内层结合，并且它们的外表面变黑。它们的核心几乎没有黑化，留下小的泡状结构。在pheomelanogenesis中，它们的数量几乎相等的羽毛和头发。黑素体没有形成，但这些体在黑素体完全分化时彼此融合形成无定形基质。
Vesiculo-globular bodies, 40 nm in diameter, are present in melanosomes. The mode of their involvement in melanosomal differentiation was studied by ultrastructural comparison of eu- and pheomelanogenesis occurring in retinal and follicular melanocytes in chickens and mice. The number and distribution of these bodies differ significantly with types of melanogenesis and tissues. They were not affected by physical stimuli or by embryonic origin of melanocytes. The earliest form of melanosomes is identical in eu- and pheomelanogenesis. The vesiculoglobular bodies are involved in organization of melanosomal constituents. In eumelanogenesis, they are more numerous in feather than in retina and hair. They are least numerous in white hair and pink eyes where melanization is blocked. During melanosomal development, they become associated with melanosomal inner lamellae and their outer surface becomes melanized. Their core is hardly melanized, leaving small vesicular structures. In pheomelanogenesis, their number is almost equal in feather and hair. Lamellae are not formed, but these bodies fuse with each other to form an amorphous matrix on complete differentiation of melanosomes.