1,3-asymmetric induction in dianionic allylation reactions of amino acid derivatives-synthesis of functionally useful enantiopure glutamates, pipecolates and pyroglutamates.
1,3-asymmetric induction in dianionic allylation reactions of amino acid derivatives-synthesis of functionally useful enantiopure glutamates, pipecolates and pyroglutamates.
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DOI：
10.1016/s0040-4039(98)00900-9
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发表时间：
1998-08-13
影响因子：
1.8
通讯作者：
Margarita, R
中科院分区：
文献类型：
--
作者：
Hanessian, S;Margarita, R
从N-Cbz和N-Boc谷氨酸酯衍生的二价阴离子在C-4进行高度立体选择性的反烯丙基化反应。研究了保护基和亲电试剂的作用。合成的应用和潜在的效用在拟肽设计也被描述。(C)1998爱思唯尔科技有限公司版权所有。
Dianions derived from N-Cbz and N-Boc glutamic acid esters undergo highly stereoselective anti allylation reactions at C-4. The roles of protecting groups and of the electrophile were studied. Synthetic applications and potential utility in peptidomimetic design are also described. (C) 1998 Elsevier Science Ltd. All rights reserved.