FUNCTIONS OF HIV ENVELOPE GLYCANS
FUNCTIONS OF HIV ENVELOPE GLYCANS
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DOI：
10.1016/0968-0004(94)90034-5
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发表时间：
1994-02-01
影响因子：
13.8
通讯作者：
JONES, IM
中科院分区：
文献类型：
--
作者：
FENOUILLET, E;GLUCKMAN, JC;JONES, IM
人类免疫缺陷病毒的主要包膜糖蛋白（gp 160）的异常高度糖基化状态给糖生物学家和病毒学家都提出了挑战。如此大量的聚糖有什么功能意义？它们是如何被操纵而使病毒致病机制处于不利地位的？这些问题的一些答案已经得到了：N-连接的聚糖是必要的创建，但不是维持，一个生物活性的构象，和药物诱导的糖基化模式的改变可能会导致受损的病毒感染性。作为研究聚糖功能的模型和抗病毒治疗的靶点，gp 160代表了一个独特的候选者。
The unusually highly glycosylated state of the major envelope glycoprotein (gp160) of the human immunodeficiency virus has offered a challenge to both glycobiologists and virologists. What is the functional significance of such a mass of glycans and how might they be manipulated to disadvantage virus pathogenesis? Some answers to each of these questions have already been obtained: N-linked glycans are necessary for the creation, but not the maintenance, of a bioactive conformation, and drug-induced alteration of the glycosylation pattern can lead to impaired virus infectivity. As a model for studying glycan function and as a target for antiviral therapy, gp160 represents a unique candidate.