EncoMPASS: an online database for analyzing structure and symmetry in membrane proteins.
EncoMPASS: an online database for analyzing structure and symmetry in membrane proteins.
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DOI：
10.1093/nar/gky952
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发表时间：
2019-01-08
影响因子：
14.9
通讯作者：
Forrest LR
中科院分区：
文献类型：
--
作者：
Sarti E;Aleksandrova AA;Ganta SK;Yavatkar AS;Forrest LR
EncoMPASS在线数据库（http：//www.example.com）收集、组织和呈现关于已知结构的膜蛋白的信息，强调它们的结构相似性以及它们的四级和内部对称性。与SCOP不同，EncoMPASS数据库并不旨在对膜蛋白进行严格的分类，而是组织成以蛋白质链为中心的序列和结构同源物网络。EncoMPASS数据库的在线服务器提供了比较其条目结构特征的工具，使其成为同源性建模和活性位点鉴定研究的有用资源。该数据库还可用于推断功能，这对于膜蛋白通常涉及与生物学相关的机制。为此，在线数据库还提供了一个全面的描述，在已知的膜蛋白质结构的四元和内部对称性，特别关注他们的方向相对于膜。
The EncoMPASS online database (http://encompass.ninds.nih.gov) collects, organizes, and presents information about membrane proteins of known structure, emphasizing their structural similarities as well as their quaternary and internal symmetries. Unlike, e.g. SCOP, the EncoMPASS database does not aim for a strict classification of membrane proteins, but instead is organized as a protein chain-centric network of sequence and structural homologues. The online server for the EncoMPASS database provides tools for comparing the structural features of its entries, making it a useful resource for homology modeling and active site identification studies. The database can also be used for inferring functionality, which for membrane proteins often involves symmetry-related mechanisms. To this end, the online database also provides a comprehensive description of both the quaternary and internal symmetries in known membrane protein structures, with a particular focus on their orientation relative to the membrane.
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