Genetic resistance to bovine tuberculosis in the Iberian wild boar
Genetic resistance to bovine tuberculosis in the Iberian wild boar
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DOI：
10.1111/j.1365-294x.2005.02656.x
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发表时间：
2005-09-01
影响因子：
4.9
通讯作者：
Amos, W
中科院分区：
文献类型：
--
作者：
Acevedo-Whitehouse, K;Vicente, J;Amos, W
牛结核病（Bovine tuberculosis，bTB）是一种重要的人畜共患传染病，给人类造成了巨大的经济损失，也制约了动物及其产品的国际贸易。尽管实施了根除方案，但一些国家继续面临疫情，主要是由于野生动物充当了主要宿主或宿主。虽然人类和牛的结核病的遗传成分是有据可查的，但遗传因素作为bTB耐药性调节剂的作用在自然人群中仍不清楚。为了解决这一问题，我们调查了西班牙南部野猪对bTB感染和疾病进展的易感性的宿主遗传变异的相对贡献。我们发现，遗传杂合性是bTB的一个重要预测因子，不仅调节对感染的抵抗力，而且影响感染个体对疾病进展的遏制。我们的研究结果提供了进一步的证据，宿主遗传变异在自然种群中起着核心作用。分别测试每个标记揭示了对bTB的一般和单位点关联效应的证据，并且几个位点揭示了与具有已知免疫功能的基因组区域的高度同源性。我们的研究结果可能对了解野生动物中可能影响家畜和人类的bTB爆发至关重要。
Bovine tuberculosis (bTB) is an important re-emerging zoonotic disease, causing major economic losses and constraining international trade of animals and their products. Despite eradication programmes, some countries continue to encounter outbreaks, mainly due to wildlife acting as primary hosts or reservoirs. While the genetic component of tuberculosis in humans and cattle is well documented, the role of genetic factors as modulators of bTB resistance remains unclear for natural populations. To address this issue, we investigated the relative contribution of host genetic variability to susceptibility to bTB infection and disease progression in wild boars from southern Spain. We found that genetic heterozygosity is an important predictor of bTB, not only modulating resistance to infection but also influencing containment of disease progression in infected individuals. Our results provide further evidence that host genetic variability plays a central role in natural populations. Testing each marker separately reveals evidence of both general and single-locus associative effects on bTB and several loci reveal high homology to regions of the genome with known immune function. Our results may prove to be crucial for understanding outbreaks of bTB in wildlife that could potentially affect domestic livestock and humans.