Irritability in Children and Adolescents
Irritability in Children and Adolescents
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DOI：
10.1146/annurev-clinpsy-032816-044941
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发表时间：
2017-01-01
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影响因子：
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通讯作者：
Leibenluft, Ellen
中科院分区：
文献类型：
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作者：
Brotman, Melissa A.;Kircanski, Katharina;Leibenluft, Ellen
易怒是儿童和青少年常见的损害性临床表现。尽管它对公众健康有重大影响，但易怒仍然是一个难以捉摸的概念。慢性和严重的易怒是新的DSM-5诊断的主要症状，破坏性情绪失调障碍（DMDD）。然而，经验和临床方法的易怒是在他们的相对婴儿期，并提出了关于DMDD诊断的有效性问题。此外，易怒是一种在青年中持续分布的特征，因此符合国家心理健康研究所研究领域标准倡议。因此，有机会进行科学审查和整合。因此，本综述的目的包括：（a）阐明应激的定义，结合临床和翻译动物工作;（B）回顾应激研究的历史背景;（c）回顾应激的流行、临床相关性和纵向过程;（d）介绍与应激相关的行为和神经生物学发现;（e）回顾应激的研究进展;（f）回顾应激的临床和翻译研究。及（e）探讨治疗方案及建议未来的研究方向。
Irritability is a common and impairing clinical presentation in children and adolescents. Despite its significant public health impact, irritability remains an elusive construct. Chronic and severe irritability is the primary symptom of the new DSM-5 diagnosis, disruptive mood dysregulation disorder (DMDD). However, empirical and clinical approaches to irritability are in their relative infancy, and questions regarding the validity of the DMDD diagnosis have been raised. Moreover, irritability is a trait distributed continuously in youth, thereby fitting within the National Institute of Mental Health Research Domain Criteria initiative. Thus, there are opportunities for scientific review and integration. Accordingly, the goals of this review include (a) clarifying the definitions of irritability, incorporating clinical and translational animal work; (b) reviewing the historical context surrounding the study of irritability; (c) reviewing the prevalence, clinical correlates, and longitudinal course of irritability; (d) presenting behavioral and neurobiological findings associated with irritability; and (e) exploring treatment options and proposing future directions for research.