Resveratrol alleviates zea-induced decidualization disturbance in human endometrial stromal cells.
Resveratrol alleviates zea-induced decidualization disturbance in human endometrial stromal cells.
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DOI：
10.1016/j.ecoenv.2020.111511
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发表时间：
2021-01
影响因子：
6.8
通讯作者：
S. Yao;Wei Wei-Wei;Rui Cao;Lin Lu;Shijin Liang;Mingjun Xiong;Chen Zhang;Xiao-huan Liang;Yongjiang Ma
中科院分区：
文献类型：
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作者：
S. Yao;Wei Wei-Wei;Rui Cao;Lin Lu;Shijin Liang;Mingjun Xiong;Chen Zhang;Xiao-huan Liang;Yongjiang Ma
蜕膜化是人类妊娠的关键过程，它赋予子宫内膜接受发育中胚胎的能力，并为后续生长维持适当的环境。卵巢类固醇激素雌激素和孕激素之间的微妙协作控制着蜕膜化和随后的胚胎着床的建立过程。玉米赤霉烯酮（ZEA）是一种具有雌激素活性的内分泌干扰物。在这项研究中，我们研究了ZEA对人子宫内膜间质细胞蜕膜化的影响。结果表明，ZEA通过抑制ERα核转位发挥其抑制作用。ZEA暴露导致蜕膜化进程受阻，雌激素受体拮抗剂可减弱这种作用。值得注意的是，白藜芦醇（RSV）管理恢复受损的蜕膜化过程中诱导抗氧化基因谷胱甘肽过氧化物酶3（GPX3）。这项研究提供了新的见解ZEA在人类蜕膜基质细胞的不良反应的机制，并建议RSV的潜在治疗候选人，以减轻ZEA诱导的细胞毒性在蜕膜化。
Decidualization, which endows the endometrium competency to adopt developing embryo and maintain appropriate milieu for following growth, is a pivotal process for human pregnancy. The delicate collaboration between ovarian steroid hormones estrogen and progesterone governs the process of decidualization and subsequent establishment of embryo implantation. Mycotoxin zearalenone (ZEA) is well known as endocrine disruptor due to its potent estrogenic activity. In this study, we investigated effects of ZEA on decidualization of human endometrial stromal cells. Results indicated that ZEA exhibited its inhibitory action through nuclear translocation of ERα. ZEA exposure led to dampened progress of decidualization, which could be attenuated by estrogen receptor antagonist. Notably, resveratrol (RSV) administration restored impaired decidualization process by induction of anti-oxidative gene glutathione peroxidase 3 (GPX3). This study provides novel insights into the mechanism underlying adverse effects of ZEA in human decidual stromal cells and suggests RSV a potential therapeutic candidate to alleviate ZEA-induced cytotoxicity during decidualization.