Small dense LDL-cholesterol relative to LDL-cholesterol is a strong independent determinant of hypoadiponectinemia in metabolic syndrome
Small dense LDL-cholesterol relative to LDL-cholesterol is a strong independent determinant of hypoadiponectinemia in metabolic syndrome
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DOI：
10.1253/circj.72.932
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发表时间：
2008-06-01
影响因子：
3.3
通讯作者：
Hasegawa, Koji
中科院分区：
文献类型：
--
作者：
Satoh, Noriko;Wada, Hiromichi;Hasegawa, Koji
背景小密度低密度脂蛋白（sd-LDL）是一种与心血管疾病风险增加密切相关的致动脉粥样硬化脂蛋白。然而，对代谢综合征（MS）患者体内sd- ldl -胆固醇（sd-LDL-C）的实际含量尚未进行精确分析。方法与结果本研究纳入的214例患者中，101例（47%）符合日本多发性硬化症标准。双检测HPLC系统检测MS患者血清sd-LDL-C水平高于非MS患者，而MS患者与非MS患者的总胆固醇和低密度脂蛋白胆固醇（LDL-C）相似。与sd-LDL-C和LDL-C水平相比，sd-LDL-C/LDL-C比值与ms相关的各项参数关系更为密切。多因素回归分析显示，sd-LDL-C/LDL-C比值是低脂联素血症的最强独立决定因素。此外，通过饮食和运动减肥治疗可以迅速降低LDL-C，但降低sd-LDL-C的速度较慢。在治疗后12个月，体重减轻导致sd-LDL-C/LDL-C比值显著下降，同时脂联素水平升高。结论sd-LDL-C/LDL-C比值与低脂联素血症密切相关，为ms提供了一个有用的临床指标。结果还表明，该比值的升高可以通过长期生活方式的改变来调节。
Background Small dense low-density lipoprotein (sd-LDL) is an atherogenic lipoprotein closely associated with an increased risk of cardiovascular diseases. However, a precise analysis of the actual amount of sd-LDL-cholesterol (sd-LDL-C) in patients with metabolic syndrome (MS) has not been performed.Methods and Results Among 214 patients enrolled in the present study, 101 patients (47%) met the Japanese MS criteria. The serum levels of sd-LDL-C determined with a dual detection HPLC system were higher in MS than non-MS patients, while total cholesterol and low-density lipoprotein-cholesterol (LDL-C) were similar between MS and non-MS patients. Compared with the sd-LDL-C and LDL-C level, the ratio sd-LDL-C/LDL-C was more closely correlated with various parameters associated with MS. A multivariate regression analysis revealed that the ratio sd-LDL-C/LDL-C is the strongest independent determinant of hypoadiponectinemia. Furthermore, weight reduction therapy through diet and exercise rapidly decreased LDL-C but slowly decreased sd-LDL-C. At 12 months after the therapy, weight reduction led to a significant decrease in the ratio sd-LDL-C/LDL-C in tandem with increasing adiponectin levels.Conclusions These findings demonstrate that the ratio sd-LDL-C/LDL-C is tightly connected with hypoadiponectinemia and provides a useful clinical indicator for MS. The results also suggest that the elevation of this ratio can be modulated by long-term lifestyle changes.