THE INFLUENCE OF PARTICLE-SIZE OF LIPOSOMES ON THE DEPOSITION OF DRUG INTO SKIN
THE INFLUENCE OF PARTICLE-SIZE OF LIPOSOMES ON THE DEPOSITION OF DRUG INTO SKIN
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DOI：
10.1016/0378-5173(94)90178-3
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发表时间：
1994-03-30
影响因子：
5.8
通讯作者：
MULLER, DG
中科院分区：
文献类型：
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作者：
DUPLESSIS, J;RAMACHANDRAN, C;MULLER, DG
以无毛小鼠、仓鼠和猪皮为实验对象，研究了脂质体粒径对药物在皮肤层沉积的影响。体外扩散研究旨在寻找局部给药的最佳配方，并试图解释脂质体局部给药的机制。结果表明，存在最佳给药粒度。研究证明，卵泡途径在决定药物从脂质体转移到皮肤的动力学中起重要作用。
The effect of particle size of liposomes on the deposition of drugs into the strata of skin was evaluated using hairless mice, hamster and pig skin. In vitro diffusion studies were performed in an attempt to find an optimum formulation for topical drug delivery as well as to try to explain the mechanism of topical drug delivery by liposomes. The results indicate that an optimum particle size for optimal drug delivery exists. The study proved that the follicular route play an important role in determining the kinetics of drug transfer from liposomes into the skin.