Atmospheric pressure and seizure frequency in the epilepsy unit: Preliminary observations
Atmospheric pressure and seizure frequency in the epilepsy unit: Preliminary observations
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DOI：
10.1111/j.1528-1167.2007.01111.x
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发表时间：
2007-09-01
期刊：
影响因子：
5.6
通讯作者：
Haltiner, Alan M.
中科院分区：
文献类型：
--
作者：
Doherty, Michael J.;Youn, Clover;Haltiner, Alan M.
目的：证明接受视频脑电图遥测的患者的癫痫发作频率与大气压 (AP) 变化无关。方法：西雅图都会区气象站的历史自动 AP 数据与 2005 年 4 月至 2006 年 4 月在我们机构接受视频脑电图遥测的连续患者的癫痫发作频率和类型相关。每日最大、最小和大气压范围与每日次数相关。 每个患者的事件（癫痫发作、假性癫痫发作、未知）。或者，事件是否发生在每天大于或小于 5.5 mBar 的变化期间，用于评估事件发生的优势比。 结果：在 191 名患者中，96 名被诊断为癫痫，60 名患有假性癫痫，40 名有不同的诊断。总共发生了 159 次癫痫发作、59 次假性癫痫发作和 40 次未知事件。每日平均、最大或最小压力变化与癫痫发作或其他事件频率之间没有相关性。随着每日 AP 范围的增加，每个已知癫痫患者的每日癫痫发作次数也随之增加 (P = 0.03)。如果当天气压变化超过 5.5 mBar，已知癫痫患者的癫痫发作的 OR 为 2.80 (95% CI 1.22-6.42 P = 0.02)。结论：令人惊讶的是，在已知癫痫患者中，癫痫发作频率随着气压变化而增加，特别是每天超过 5.5 mBar 范围。讨论了 AP 变化对癫痫易感性的推测机制。
Objective: To demonstrate that seizure frequency in patients undergoing video EEG telemetry does not correlate with atmospheric pressure (AP) changes.Method: Historical automated AP data from weather stations in the Seattle Metropolitan area were correlated to seizure frequency and type in consecutive patients undergoing video EEG telemetry at our institution from April 2005-April 2006. Daily maximum, minimum and range of atmospheric pressures were correlated to daily number of events (seizures, pseudoseizures, unknown) per patient. Alternatively, whether or not events occurred during a change of greater or less than 5.5 mBar per day were used to evaluate odds ratios of events occurring.Results: Of 191 patients, 96 were diagnosed with epilepsy, 60 with pseudoseizures, and 40 had different diagnoses. A total of 159 seizures, 59 pseudoseizures, and 40 unknown events occurred. No correlation between daily mean, maximum or minimum pressure change with seizure or other event frequency was seen. With increased daily AP range an increase in daily seizure per known seizure patient occurred (P = 0.03). Patients with known epilepsy showed an OR of a seizure occurring of 2.80 (95% CI 1.22-6.42 P = 0.02) if pressure changed more than 5.5 mBar that day.Conclusions: Surprisingly, in patients with known epilepsy, increased seizure frequency occurred with changes in barometric pressure, particularly over 5.5 mBar range per day. Speculative mechanisms of AP change on seizure susceptibility are discussed.