Prostaglandin E2 - Making more of your marrow
Prostaglandin E2 - Making more of your marrow
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DOI：
10.4161/cc.6.24.5129
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发表时间：
2007-12-15
期刊：
影响因子：
4.3
通讯作者：
Zon, Leonard I.
中科院分区：
文献类型：
--
作者：
Lord, Allegra M.;North, Trista E.;Zon, Leonard I.
我们最近通过斑马鱼胚胎的化学筛选证明，前列腺素E2(PGE2)是一种进化上保守的造血干细胞(HSC)数量调节因子。在小鼠模型上的体外和体内研究进一步证实了这些结果。生物活性PGE2衍生物在促进化疗或放疗后的造血系统恢复方面具有潜在的临床应用价值。干细胞移植前的体外扩增可能会促进造血和免疫功能的重建。本文旨在总结前列腺素E_2介导的血细胞稳态调节的现有知识，并讨论在临床环境下使用前列腺素E_2扩增造血干细胞以供移植的建议。
We have recently demonstrated through a chemical screen in the zebrafish embryo that prostaglandin E2 (PGE2) is an evolutionarily conserved regulator of hematopoietic stem cell (HSC) number. These results have further been confirmed by in vitro and in vivo studies in the murine model. Bioactive PGE2 derivatives have potential clinical application to accelerate recovery of the hematopoietic system following chemotherapy or irradiation. Ex vivo expansion of HSCs prior to stem cell transplantation may improve reconstitution of hematopoiesis and immune function. This article aims to summarize current knowledge of PGE2-mediated regulation of blood cell homeostasis as well as to discuss the proposed use of PGE2 to expand hematopoietic stem cells for transplantation in the clinical setting.