SUPPLEMENTARY EYE FIELD AS DEFINED BY INTRACORTICAL MICROSTIMULATION - CONNECTIONS IN MACAQUES
SUPPLEMENTARY EYE FIELD AS DEFINED BY INTRACORTICAL MICROSTIMULATION - CONNECTIONS IN MACAQUES
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DOI：
10.1002/cne.902930211
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发表时间：
1990-03-08
影响因子：
2.5
通讯作者：
KAAS, JH
中科院分区：
文献类型：
--
作者：
HUERTA, MF;KAAS, JH
在猕猴中，额眼区域和最近定义的辅助眼区域在眼球运动的产生中发挥着作用。虽然额眼区域的结构和功能已广为人知，但对于辅助眼区域却知之甚少。本研究的目的是确定生理学定义的辅助眼场的连接。在每种情况下，通过使用皮质内微刺激来确定辅助眼野的位置，在边界上标记小电解损伤，并将与麦芽凝集素缀合的辣根过氧化物酶注射到辅助眼野中。将组织与四甲基联苯胺一起孵育后，确定在三种情况下注射部位仅限于生理学定义的辅助眼野。目前的结果表明，辅助眼野与屏状体、腹前核相互连接，包括大细胞部、X核、腹外侧核的后部细分、内侧背核、中央外侧核、束旁核的多形性、小细胞性、大细胞性和密细胞性细分， 和上膝限制复合体。辅助眼野投射到壳核、尾状核、丘脑网状核、中央密细胞核、未定带、底丘脑核、内侧纵束头侧间质核、红核小细胞部分、上丘中深层、中央灰质、楔形核、 中脑网状结构、脑桥灰质、脑桥被盖网状核和口桥网状核。辅助眼区与主周和下前额叶皮层、弓状周皮层（包括额眼区、额腹区）和弓状前运动皮层以及辅助眼区周围的皮层（包括辅助运动区）相互和双边连接。辅助眼野还与扣带沟和顶内沟内部及其周围的皮层同侧相互连接，而颞上沟内的皮层投射到辅助眼野。将生理学定义的辅助眼场的连接与先前演示的辅助运动区域和生理学定义的额眼场的连接进行比较。比较额眼区和辅助眼区的连接，发现两个区域都与视觉运动功能相关的结构有联系，但额眼区与视觉相关结构的联系更广泛，辅助眼区与前额叶和骨骼运动功能相关的结构有更广泛的联系。这种连接差异表明额叶这两个感觉运动区域之间的功能差异。
In macaques, the frontal eye field and the recently defined supplementary eye field play a role in the production of eye movements. Whereas the structure and function of the frontal eye field are well understood, little is known about the supplementary eye field. The goal of this study was to determine the connections of the physiologically defined supplementary eye field. In each case, the location of the supplementary eye field was determined by using intracortical microstimulation, the borders were marked with small electrolytic lesions, and horseradish peroxidase conjugated to wheat germ agglutinin was injected into the supplementary eye field. After the tissue was incubated with tetramethyl benzidine, it was determined that in three cases the injection site was confined to the physiologically defined supplementary eye field. The present results indicate that the supplementary eye field is reciprocally connected with the claustrum, ventral anterior nucleus, including pars magnocellularis, nucleus X, posterior subdivisions of the ventral lateral nucleus, multiform, parvocellular, magnocellular, and densocellular subdivisions of the smedial dorsal nucleus, central lateral nucleus, parafascicular nucleus, and suprageniculate-limitans complex. The supplementary eye field projects to the putamen, caudate, reticular nucleus of the thalamus, central densocellular nucleus, zona incerta, subthalamic nucleus, rostral interstitial nucleus of the medial longitudinal fasciculus, parvocellular part of the red nucleus, intermediate and deep layers of the superior colliculus, central gray, cuneiform nucleus, mesencephalic reticular formation, pontine gray, nucleus reticularis tegmenti pontis, and nucleus reticularis pontis oralis. The supplementary eye field is reiprocally and bilaterally connected with periprincipal and inferior prefrontal cortex, with periarcuate cortex, including the frontal eye field, the frontal ventral region, and with postarcuate premotor cortex, and cortex surrounding the supplementary eye field, including the supplementary motor area. The supplementary eye field is also reciprocally connected ipsilaterally with cortex in and around the cingulate sulcus and the intraparietal sulcus, whereas cortex within the superior temporal sulcus projects to the supplementary eye field. The connections of the physiologically defined supplementary eye field are compared to previously demonstrated connections of the supplementary motor region and of the physiologically defined frontal eye field. Comparisons between the connections of the frontal and supplementary eye fields reveal that both regions are connected with structures related to visuomotor functions, but the frontal eye field has more extensive connections with vision-related structures, and the supplementary eye field has more extensive connections with structures related to prefrontal and skeletomotor functions. Such connectional differences suggest functional differences between these two sensorimotor regions of the frontal lobe.