Characterization of Interleukin-33 and Soluble ST2 in Serum and Their Association with Disease Severity in Patients with Chronic Kidney Disease
Characterization of Interleukin-33 and Soluble ST2 in Serum and Their Association with Disease Severity in Patients with Chronic Kidney Disease
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DOI：
10.1007/s10875-011-9622-7
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发表时间：
2012-06-01
影响因子：
9.1
通讯作者：
Xie, Ru-Juan
中科院分区：
文献类型：
--
作者：
Bao, Yu-Shi;Na, Shi-Ping;Xie, Ru-Juan
本研究旨在检测慢性肾脏病（CKD）患者血清白细胞介素-33（IL-33）和可溶性ST 2（sST 2）水平，并评估其与疾病严重程度的关系。12名健康志愿者作为健康个体。结果根据肾小球滤过率（eGFR）将患者分为5类。CKD患者和健康个体之间的IL-33血清浓度无差异（p=0.656），而CKD患者中发现较高的sST 2血清水平（p=0.003）。相关分析显示sST 2水平与疾病严重程度显著相关（r=0.586; p
Introduction This study aims to test the serum levels of interleukin-33 (IL-33) and soluble ST2 (sST2) in patients with chronic kidney disease (CKD) and to evaluate their association with disease severity.Methods Sixty-nine patients with CKD were enrolled, disease severity was assessed, and clinical data were collected. Twelve healthy volunteers served as healthy individuals. Serum IL-33 and sST2 were tested by enzyme-linked immunosorbent assay.Results The patients were classified into five categories based on their estimated glomerular filtration rate (eGFR). No difference was found as to the serum concentration of IL-33 between CKD patients and healthy individuals (p=0.656), while a higher serum level of sST2 was found in CKD patients (p=0.003). The correlation analysis revealed a significant correlation between the serum level of sST2 and disease severity (r=0.586; p