N‐myc Oncogene Amplification in a Patient with IV‐S Neuroblastoma
N‐myc Oncogene Amplification in a Patient with IV‐S Neuroblastoma
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IV-S 神经母细胞瘤患者的 N-myc 癌基因扩增
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
P. Cornaglia‐Ferraris
中科院分区：
文献类型：
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作者：
G. Tonini;G. Verdona;B. Bernardi;R. Sansone;L. Massimo;P. Cornaglia‐Ferraris
神经母细胞瘤（NB）是一种肿瘤，通常发生在儿童和年轻人显示不同程度的恶性。最近，成神经细胞中N-myc扩增的存在与疾病晚期的不良结局相关（Evans IV期）。迄今为止，在通常被认为预后良好的IV-S期中未观察到N-myc基因扩增。在本文中，我们报告的情况下，受NB阶段IV-S显示轻度N-myc基因扩增的儿童。在我们的病人中发现的N-myc扩增表明，这种改变的N-myc癌基因不一定与预后不良;在这个光N-myc扩增的作用在肿瘤的过程中应重新考虑。
Neuroblastoma (NB) is a tumor usually arising in children and young adults showing different degrees of malignancy. Recently, the presence of N-myc amplification in neuroblasts has been associated with a poor outcome in the late stages of disease (Evans's Stage IV). Until now no amplification of N-myc gene has been observed in Stage IV-S, usually considered to have a favorable prognosis. In this paper we report a case of a child affected by NB Stage IV-S showing mild N-myc gene amplification. The finding of N-myc amplification in our patient shows that such alteration of the N-myc oncogene is not necessarily correlated with a poor prognosis; in this light the role of N-myc amplification in the neoplastic process should be reconsidered.