The disruption of white matter integrity of systemic striatal circuits in alcohol-dependent males with physiological cue reactivity
The disruption of white matter integrity of systemic striatal circuits in alcohol-dependent males with physiological cue reactivity
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DOI：
10.1111/adb.13273
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发表时间：
2023-04-01
影响因子：
3.4
通讯作者：
Sun，Hongqiang
中科院分区：
文献类型：
--
作者：
Wu，Fei;Dong，Ping;Sun，Hongqiang
酒精依赖（Alcohol Dependence，AD）是一种慢性复发性疾病。与药物的奖励特性相关的条件性线索可能引发动机/生理反应，并使受试者容易复发。纹状体回路功能障碍与酒精成瘾行为有关。然而，鲜为人知的是，纹状体结构连接的变化背后的线索诱导的反应，在AD。在我们目前的研究中，我们招募了51例AD患者，其中31人有生理反应。我们使用基于种子的分类，通过概率纤维束成像和9个目标掩模来探索生理应答者（N= 31）、无应答者（N= 20）和健康对照者（N= 27）中纹状体回路的白色物质完整性。与健康对照组相比，生理反应者在纹状体-背外侧前额叶皮质（dlPFC）、纹状体-腹外侧前额叶皮质、纹状体-补充运动区（SMA）和纹状体-岛叶中显示出较低的各向异性分数（FA）和/或较高的平均扩散率。考虑到年龄和吸烟是扩散参数的潜在干扰因素，我们还进行了协方差分析，发现了类似的结果，我们还发现提示诱导的生理反应与AD患者纹状体-SMA（r =-0.287;p =0.045）和左侧纹状体-dlPFC（r =-0.253;p =0.079）的FA呈负相关。在我们的研究中，我们发现AD患者的纹状体回路结构连接的完整性异常，具有生理线索反应性，特别是来自前额叶皮层和岛叶的轨迹。我们还发现纹状体径迹的FA与线索反应的程度呈负相关。我们的研究结果提供了进一步的证据，减少白色物质的完整性纹状体电路的线索反应，在男性个体与AD。
Alcohol dependence (AD) is a chronic and relapsing disorder. Conditioned cues associated with the rewarding properties of drugs could trigger motivational/physiological reactions and render subjects vulnerable to relapse. Striatal circuit dysfunction has been implicated in alcohol addiction behaviours. However, little is known about the striatal tracts structural connectivity changes underlying cue induced reactivity in AD. In our present study, we recruited 51 patients with AD; 31 individuals had physiological response. We used seed‐based classification by probabilistic tractography with nine target masks to explore the white matter integrity of striatal circuits in physiological responders (N= 31), non‐responders (N= 20), and healthy controls (N= 27). Compared with healthy controls, physiological responders showed lower fractional anisotropy (FA) and/or higher mean diffusivity in the striatum‐dorsolateral prefrontal cortex (dlPFC), striatum‐ventral lateral prefrontal cortex, striatum‐supplementary motor area (SMA), and striatum‐insular. Considering age and smoking are potential nuisances to diffusion parameters, an analysis of covariance also was conducted and similar results were found. We also found the cue‐induced physiological response was negatively associated with the FA of the striatum‐SMA (r = −0.287;p =0.045) and left striatum‐dlPFC (r = −0.253;p =0.079) in AD. In our study, we found abnormal integrity of striatal circuit structural connectivity in AD with physiological cue reactivity, especially trajectory from prefrontal cortex and insular. We also found the FA of striatal tracks was negatively associated with the degree of cue reactivity. Our findings provide further evidence for reduced white matter integrity of striatal circuits for cue reactivity in male individuals with AD.