A CASE OF CAT SCRATCH DISEASE DIAGNOSED BY INDIRECT FLUORESCENT ANTIBODY ASSAY OF IGM SPECIFIC FOR A JAPANESE STRAIN OF Bartonella henselae
A CASE OF CAT SCRATCH DISEASE DIAGNOSED BY INDIRECT FLUORESCENT ANTIBODY ASSAY OF IGM SPECIFIC FOR A JAPANESE STRAIN OF Bartonella henselae
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日本汉赛巴尔通体IGM抗体间接荧光检测诊断猫抓病一例
DOI：
10.1097/icb.0000000000000854
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发表时间：
2019
影响因子：
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通讯作者：
Kimura Kazuhiro
中科院分区：
文献类型：
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作者：
Uchi Sho-Hei;Yanai Ryoji;Tsuneoka Hidehiro;Otsuyama Ken-ichiro;Sonoda Koh-Hei;Kimura Kazuhiro
目的：报道一例应用间接荧光抗体(IFA)检测日本新近发现的汉氏巴尔通体(YH-01)株免疫球蛋白M(IgM)，诊断为猫抓病相关性视网膜炎。方法：报道1例24岁孕妇，表现为全身发热、乏力、视力模糊、右眼中央视野缺陷，因一个月前开始喂食野狗而被怀疑为猫抓病。结果：患者血清检测结果为阴性，但对休斯顿-1、休斯顿-1、休斯顿-1、休斯顿-1、休斯顿-1、休斯顿-1、休斯顿-1和休斯顿-1的患者进行免疫球蛋白M或IgM的间接荧光抗体检测。亨塞雷氏杆菌的常见菌株。用IFA法进一步检测YH-01毒株的特异性IgM，结果为阳性。根据临床表现和IFA结果，我们能够对猫抓病做出明确的诊断。结论：基于YH-01或YH-01和休斯顿-1两株亨氏不动杆菌联合使用的IFA方法对日本猫抓病的诊断具有更高的敏感性。
Purpose:To report a case of cat scratch disease–associated retinitis diagnosed with an indirect fluorescent antibody (IFA) assay for immunoglobulin M (IgM) specific for a strain (YH-01) of Bartonella henselae recently identified in Japan.Methods:Case report of a 24-year-old pregnant woman presented with general fever, fatigue, as well as blurred vision, and a central visual field deficiency in her right eye and was suspected as cat scratch disease because she had started to feed a feral dog a month ago.Results:The patient's serum tested negative, however, with an IFA assay for IgG or IgM specific for the Houston-1, common strain of B. henselae. Further testing with an IFA assay for IgM specific for the YH-01 strain yielded a positive result. On the basis of the clinical findings and the IFA results, we were thus able to make a definitive diagnosis of cat scratch disease.Conclusion:An IFA assay based on the YH-01 or combination of both YH-01 and Houston-1 strains of B. henselae may show increased sensitivity for the diagnosis of cat scratch disease in Japan.