Current Progress in Delineating the Roles of Pseudokinase TRIB1 in Controlling Human Diseases.
Current Progress in Delineating the Roles of Pseudokinase TRIB1 in Controlling Human Diseases.
复制标题
拟激酶 TRIB1 在控制人类疾病中作用的最新进展
DOI：
10.7150/jca.51627
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发表时间：
2021
影响因子：
3.9
通讯作者：
Sun X
中科院分区：
文献类型：
--
作者：
Zhang X;Zhang B;Zhang C;Sun G;Sun X
Tribbles同源物1（TRIB 1）是假蛋白激酶的Tribbles家族的成员，并且在许多组织中广泛表达，如骨髓、骨骼肌、肝脏、心脏和脂肪组织。它与急性髓性白血病、前列腺癌、肿瘤耐药性密切相关，并能干扰造血干细胞周期，促进肿瘤细胞增殖，抑制细胞凋亡。近年来的研究表明，TRIB 1可通过影响炎症因子的分泌来调节急性和慢性炎症，与高脂血症和心血管疾病的发生密切相关。鉴于TRIB 1的重要生物学功能，迄今发表的综述不够全面。本文综述了TRIB 1的研究进展，旨在探讨其在肿瘤、高脂血症和心血管疾病中的作用，为进一步研究TRIB 1的生物学作用提供理论基础。
Tribbles homolog 1 (TRIB1) is a member of the tribbles family of pseudoprotein kinases and is widely expressed in numerous tissues, such as bone marrow, skeletal muscle, liver, heart, and adipose tissue. It is closely associated with acute myeloid leukemia, prostate cancer, and tumor drug resistance, and can interfere with the hematopoietic stem cell cycle, promote tumor cell proliferation, and inhibit apoptosis. Recent studies have shown that TRIB1 can regulate acute and chronic inflammation by affecting the secretion of inflammatory factors, which is closely related to the occurrence of hyperlipidemia and cardiovascular diseases. Given the important biological functions of TRIB1, the reviews published till now are not sufficiently comprehensive. Therefore, this paper reviews the progress in TRIB1 research aimed at exploring its roles in cancer, hyperlipidemia, and cardiovascular disease, and providing a theoretical basis for further studies on the biological roles of TRIB1.
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