Dectin-1 is not required for the host defense to Cryptococcus neoformans
Dectin-1 is not required for the host defense to Cryptococcus neoformans
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DOI：
10.1111/j.1348-0421.2007.tb04007.x
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发表时间：
2007-01-01
影响因子：
2.6
通讯作者：
Kawakami, Kazuyoshi
中科院分区：
文献类型：
--
作者：
Nakamura, Kiwamu;Kinjo, Takeshi;Kawakami, Kazuyoshi
Dectin-1是已知的P-葡聚糖的唯一受体，P-葡聚糖是真菌微生物的主要细胞壁成分。在目前的研究中，我们研究了这种分子在宿主防御新生隐球菌中的作用，新生隐球菌是艾滋病患者的一种机会性真菌病原体。Dectin-1基因缺陷小鼠的临床病程和细胞因子的产生与对照组无显著差异。这些结果表明Dectin-1在宿主对新生链球菌的保护性反应中可能不是必需的。
Dectin-1 is known as a sole receptor for P-glucan, a major cell wall component of fungal microorganisms. In the current study, we examined the role of this molecule in the host defense to Cryptococcus neoformans, an opportunistic fungal pathogen in AIDS patients. There was no significant difference in the clinical course and cytokine production between dectin-1 gene-deficient and control mice. These results indicate that dectin-1 is not likely essential for the development of host protective responses to C neoformans.