Education and other measures of socioeconomic status and risk of incident Alzheimer disease in a defined population of older persons
Education and other measures of socioeconomic status and risk of incident Alzheimer disease in a defined population of older persons
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DOI：
10.1001/archneur.1997.00550230066019
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发表时间：
1997-11-01
影响因子：
--
通讯作者：
Taylor, JO
中科院分区：
文献类型：
--
作者：
Evans, DA;Hebert, LE;Taylor, JO
目的：评价社会经济地位的3项指标(教育程度、职业声望和收入)与临床诊断为阿尔茨海默病(AD)事件风险的关系。设计：队列研究，平均观察时间为4.3年。地点：马萨诸塞州东波士顿，一个地理定义的社区。参与者：对642名65岁及以上的社区居民进行分层随机抽样，以基线为基准。主要观察指标：根据标准诊断可能的AD，采用结构化统一评估。结果：采用Logistic回归分析评估了这3项社会经济状况指标与疾病风险的关系。在个人分析中，受过较少正规教育的年限、较低的收入和较低的职业地位都预示着AD事件的风险；每受教育一年，疾病风险降低约17%。在包含所有3个指标的分析中，教育对疾病风险的影响大致相同，但其他2个指标的影响略小，没有达到正式的统计学意义，每项指标的单独分析。结论：社会经济地位较低的标记物预测AD事件的风险。这种关系的机制尚不确定，但它反映了这种疾病的不明和潜在的可逆风险因素的可能性值得仔细调查。
Objective: To assess the relations of 3 measures of socioeconomic status (education, occupational prestige, and income) to risk of incident clinically diagnosed Alzheimer disease (AD).Design: Cohort study with an average observation of 4.3 years.Setting: East Boston, Mass, a geographically defined community.Participants: A stratified random sample of 642 community residents 65 years of age and older who were free of AD at baseline.Main Outcome Measure: Clinical diagnosis of probable AD according to standard criteria, using structured uniform evaluation.Results: The relations of the 3 measures of socioeconomic status to risk of disease were assessed using logistic regression analyses. In individual analyses, fewer years of formal schooling, lower income, and lower occupational status each predicted risk of incident AD; risk of disease decreased by approximately 17% for each year of education. In an analysis including all 3 measures, the effect of education on risk for disease remained approximately the same, but the effects of the other 2 measures were somewhat less and did not attain formal statistical significance, compared with separate analysis of each measure.Conclusions: Markers of lower socioeconomic status predict risk of developing incident AD. The mechanism of this relation is uncertain, but the possibility that it reflects unidentified and potentially reversible risk factors for the disease deserves careful investigation.