Pref-1, a gatekeeper of adipogenesis.
Pref-1, a gatekeeper of adipogenesis.
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DOI：
10.3389/fendo.2013.00079
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发表时间：
2013
影响因子：
5.2
通讯作者：
Sul HS
中科院分区：
文献类型：
--
作者：
Hudak CS;Sul HS
前脂肪细胞因子1 （Pref-1，也称为Dlk1/FA1）是脂肪形成的分子看门人，其作用是维持前脂肪细胞状态，阻止脂肪细胞分化。Pref-1是一种含有跨膜蛋白的表皮生长因子样重复序列，通过tnf α-转换酶（TACE）裂解生成可溶性形式，作为自分泌/旁分泌因子。Pref-1通过激活ERK/MAPK通路上调Sox9的表达，并且Pref-1与纤维连接蛋白的相互作用是抑制脂肪形成所必需的。Pref-1还能阻止棕色脂肪细胞分化及其产热功能。在这里，我们强调了Pref-1在脂肪形成中作用的最新证据。
Preadipocyte factor 1 (Pref-1, also called Dlk1/FA1) is a molecular gatekeeper of adipogenesis which acts by maintaining the preadipocyte state and preventing adipocyte differentiation. Pref-1 is made as an epidermal growth factor-like repeat containing transmembrane protein, and is cleaved by TNFα-converting enzyme (TACE) to generate a soluble form, which acts as an autocrine/paracrine factor. Pref-1 upregulates Sox9 expression by activating the ERK/MAPK pathway and the Pref-1 interaction with fibronectin is required for inhibition of adipogenesis. Pref-1 also prevents brown adipocyte differentiation and its thermogenic function. Here, we highlight the recent evidence for the role of Pref-1 in adipogenesis.