Ruthenium-catalyzed Selective Monoamination of Vicinal Diols
Ruthenium-catalyzed Selective Monoamination of Vicinal Diols
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DOI：
10.1002/cssc.200900034
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发表时间：
2009-01-01
期刊：
影响因子：
8.4
通讯作者：
Beller, Matthias
中科院分区：
文献类型：
--
作者：
Baehn, Sebastian;Tillack, Annegret;Beller, Matthias
研究了在原位生成的钌催化剂存在下邻二醇的单胺化反应。在与[Ru-3（CO）（12）]组合测试的各种膦中，N-苯基-2-（二环己基-膦基）吡咯显示出最好的性能。在优化反应条件后，该体系被应用于不同的仲胺和苯胺以及一些邻二醇。除乙二醇外，邻位二醇的单胺化选择性地发生，并且以良好的产率获得相应的氨基醇，产生水作为唯一的副产物。
The monoamination of vicinal diols in the presence of in situ generated ruthenium catalysts has been investigated. Among the various phosphines tested in combination with [Ru-3(CO)(12)], N-phenyl-2-(dicyclohexyl-phosphanyl)pyrrole showed the best performance. After optimization of the reaction conditions this system was applied to different secondary amines and anilines as well as a number of vicinal diols. With the exception of ethylene glycol, monoamination of the vicinal diols occurred selectively and the corresponding amino alcohols were obtained in good yields, producing water as the only side product.