Impact of Variation Near MC4R on Whole-body Fat Distribution, Liver Fat, and Weight Loss
Impact of Variation Near MC4R on Whole-body Fat Distribution, Liver Fat, and Weight Loss
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DOI：
10.1038/oby.2009.233
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发表时间：
2009-10-01
期刊：
影响因子：
6.9
通讯作者：
Fritsche, Andreas
中科院分区：
文献类型：
--
作者：
Haupt, Axel;Thamer, Claus;Fritsche, Andreas
黑皮质素-4受体（MC 4 R）基因位点附近的多态性与体重相关。最近的研究表明，它们影响胰岛素敏感性和代谢综合征的发病率。因此，我们假设MC 4 R附近的候选单核苷酸多态性（SNP）rs 17782313还会影响体脂分布及其在生活方式干预期间的变化。为了验证这一点，343名德国受试者进行了SNP rs 17782313的基因分型。使用磁共振技术评估身体成分。受试者的特征是口服葡萄糖耐量试验（OGTT）。一个由242名受试者组成的亚组参加了为期9个月的生活方式干预。在整个队列中，C等位基因与较高的BMI相关（P = 0.0013），但对葡萄糖耐量或胰岛素敏感性没有影响（均P >= 0.10）。SNP对总体脂（P = 0.022）和非内脏脂肪（P = 0.017）有影响，但对肝脏脂肪和内脏脂肪无影响（均P >= 0.33）。在接受生活方式干预的亚组中，SNP rs 17782313对体重或脂肪分布的变化没有影响。尽管与BMI和非内脏脂肪组织相关，SNP rs 17782313并不影响内脏脂肪组织。因此，该人类肥胖症的候选SNP可能优先影响皮下脂肪组织的积累。此外，MC 4 R附近的变化对生活方式干预期间的减肥成功没有影响。
Polymorphisms near the melanocortin-4 receptor (MC4R) gene locus are associated with body weight. Recent studies have shown that they influence insulin sensitivity and incidence of the metabolic syndrome. Thus, we hypothesized that the candidate single-nucleotide polymorphism (SNP) rs17782313 near MC4R additionally influences body fat distribution and its change during lifestyle intervention. To test this, 343 German subjects were genotyped for SNP rs17782313. Body composition was assessed using magnetic resonance technique. Subjects were characterized by an oral glucose tolerance test (OGTT). A subgroup of 242 subjects participated in a 9-month lifestyle intervention. In the overall cohort, the C allele was associated with a higher BMI (P = 0.0013), but had no impact on glucose tolerance or insulin sensitivity (all P >= 0.10). There was an effect of the SNP on total body fat (P = 0.022) and nonvisceral fat (P = 0.017), but not on liver fat and visceral fat (all P >= 0.33). In the subgroup undergoing lifestyle intervention, SNP rs17782313 had no impact on changes in body weight or fat distribution. Despite an association with BMI and nonvisceral adipose tissue, the SNP rs17782313 did not influence visceral adipose tissue. Thus, this candidate SNP for human obesity may preferentially affect the accumulation of subcutaneous adipose tissue. Furthermore, the variation near MC4R has no effect on success of weight loss during lifestyle intervention.