Three-dimensional computational model of left heart diastolic function with fluid-structure interaction
Three-dimensional computational model of left heart diastolic function with fluid-structure interaction
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DOI：
10.1115/1.429648
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发表时间：
2000-04-01
影响因子：
1.7
通讯作者：
Yoganathan, AP
中科院分区：
文献类型：
--
作者：
Lemmon, JD;Yoganathan, AP
在计算机速度和建模技术的进步的帮助下，心脏功能的计算建模在过去的二十年中持续发展。本研究的目的是开发一个计算模型，提供生理流动条件下的血液-组织相互作用，并将其应用于薄壁模型的左心。为了实现这一目标，浸没边界法被用来研究响应于流体力和组织病理生理学变化的组织和血液的相互作用。流体质量和动量守恒方程采用Patankar的半隐式压力耦合方程法（SIMPLE）求解。开发了一个左心模型来检查舒张功能，该模型由左心室、左心房和肺血流组成。模型的输入函数包括模拟过程中肺驱动压力和腔室组织特性中电荷的时间依赖关系。将从左心模型获得的结果与临床观察到的舒张期血流条件进行比较，以进行验证。通过二尖瓣的流入速度与临床值一致（E波=74.4 cm/s，A波=43 cm/s，E/A=1.73）。心房和心室的压力迹线以及整个充盈过程中心室流场的外观与心脏中观察到的一致。此外，在该模型中可以观察到心房流场，并显示了当前理论所建议的管道和泵功能。在本模型中检查心房功能的能力是先前在心脏功能的计算模拟中没有描述的。【S0148-0731（00）01302-9】。
Aided by advancements in computer speed and modeling techniques, computational modeling of cardiac function has continued to develop over the past twenty years. The goal of the current study was to develop a computational model that provides blood-tissue interaction under physiologic flow conditions, and apply it to a thin-walled model of the left heart. To accomplish this goal, the Immersed Boundary Method was used to study the interaction of the tissue and blood in response to fluid forces and changes in tissue pathophysiology. The fluid mass and momentum conservation equations were solved using Patankar's Semi-Implicit Method for Pressure Linked Equations (SIMPLE). A left heart model was developed to examine diastolic function, and consisted of the left ventricle, left atrium, and pulmonary flow. The input functions for the model included the pulmonary driving pressure and time-dependent relationship for charges in chamber tissue properties during the simulation. The results obtained from the left heart model were compared to clinically observed diastolic flow conditions for validation. The inflow velocities through the mitral valve corresponded with clinical values (E-wave =74.4 cm/s, A-wave=43 cm/s, and E/A=1.73). The pressure traces for the atrium and ventricle, and the appearance of the ventricular flow fields throughout filling, agreed with those observed in the heart. In addition, the atrial flow fields could be observed in this model and showed the conduit and pump functions that current theory suggests. The ability to examine atrial function in the present model is something not described previously in computational simulations of cardiac function. [S0148-0731(00)01302-9].