Frequency-dependent chemolocation and chemotactic target selection.
Frequency-dependent chemolocation and chemotactic target selection.
复制标题
频率依赖性化学定位和趋化靶点选择。
DOI：
10.1088/1478-3975/7/2/026003
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发表时间：
2010
期刊：
影响因子：
2
通讯作者：
Gopinathan,Ajay
中科院分区：
文献类型：
--
作者：
Nowak,SarahA;Chakrabarti,B;Chou,Tom;Gopinathan,Ajay
趋化性通常在细胞朝向静态外源性化学引诱物源的运动的背景下建模。在这里，我们提出了一个时间依赖性机制的趋化性，其中一个自我推进的粒子（如细胞）释放一种化学物质，扩散到固定的粒子（目标）和信号的生产第二化学这些目标。然后，粒子沿着第二种化学物质的浓度梯度向上移动，类似于扩散回声定位。当一个目标是存在的，我们描述探针释放策略，优化旅行的细胞的目标。在存在多个靶标的情况下，细胞选择的靶标取决于探针化学释放的强度，有趣的是，取决于探针化学释放的频率。虽然涉及一个额外的化学信号步骤，我们的化学“ping”假说允许更大的灵活性，在调节目标选择，如在许多物理或生物实现。
Chemotaxis is typically modeled in the context of cellular motion toward a static, exogenous source of chemoattractant. Here we propose a time-dependent mechanism of chemotaxis in which a self-propelled particle (eg a cell) releases a chemical that diffuses to fixed particles (targets) and signals the production of a second chemical by these targets. The particle then moves up concentration gradients of this second chemical, analogous to diffusive echolocation. When one target is present, we describe probe release strategies that optimize travel of the cell to the target. In the presence of multiple targets, the one selected by the cell depends on the strength and, interestingly, on the frequency of probe chemical release. Although involving an additional chemical signaling step, our chemical'pinging'hypothesis allows for greater flexibility in regulating target selection, as seen in a number of physical or biological realizations.