BMSCs-Derived Exosomes Ameliorate Pain Via Abrogation of Aberrant Nerve Invasion in Subchondral Bone in Lumbar Facet Joint Osteoarthritis
BMSCs-Derived Exosomes Ameliorate Pain Via Abrogation of Aberrant Nerve Invasion in Subchondral Bone in Lumbar Facet Joint Osteoarthritis
复制标题
BMSC 衍生的外泌体通过消除腰椎小关节骨关节炎软骨下骨的异常神经侵袭来减轻疼痛
DOI：
10.1002/jor.24497
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发表时间：
2019-11-05
影响因子：
2.8
通讯作者：
Cao, Yong
中科院分区：
文献类型：
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作者：
Li, Jinsong;Ding, Zhiyu;Cao, Yong
腰椎小关节骨关节炎（LFJ OA）被认为是引起下腰痛（LBP）的常见原因之一。该病的发病机制和潜在机制在很大程度上是未知的，仍然没有有效的疾病改善治疗。本研究旨在探讨来源于骨髓间充质干细胞（BMSCs）的外泌体对LFJ OA小鼠模型中LBP发病机制和行为体征的疗效。评价了用BMSC-外泌体治疗后小鼠模型中LFJ软骨下骨中软骨和异常神经侵袭的病理变化。BMSC-exosomes可通过消除LFJ软骨下骨中异常CGRP阳性神经和异常H型血管形成来减轻疼痛。此外，BMSC-外泌体减轻软骨变性并抑制抗酒石酸酸性磷酸酶表达和RANKL-RANK-TRAF 6信号传导激活，以促进软骨下骨重塑。这些结果表明，BMSC-外泌体可以减轻LBP的行为体征和LFJ OA的病理过程。BMSC-外泌体具有显著的保护作用，可能是治疗LFJ OA引起LBP的潜在治疗选择。(c)2019骨科研究学会。由威利期刊公司出版J Orthop Res
Lumbar facet joint osteoarthritis (LFJ OA) is regarded as one of the common causes of low back pain (LBP). The pathogenesis and underlying mechanism of this disease are largely unknown, there is still no effective disease-modifying therapy. This study aims to investigate the efficacy of exosomes derived from bone marrow mesenchymal stem cells (BMSCs) on the pathogenesis and behavioral signs of LBP in the LFJ OA mouse model. The pathogenetic change in cartilage and aberrant nerve invasion in the subchondral bone of LFJ in a mouse model after treatment with BMSC-exosomes was evaluated. BMSC-exosomes could relieve pain via abrogation of aberrant CGRP-positive nerve and abnormal H-type vessel formation in the subchondral bone of LFJ. Moreover, BMSC-exosomes attenuated cartilage degeneration and inhibited tartrate-resistant acid phosphatase expression and RANKL-RANK-TRAF6 signaling activation to facilitate subchondral bone remodeling. These results indicated that BMSC-exosomes could relive behavioral signs of LBP and pathological processes in LFJ OA. BMSC-exosomes have a prominent protective effect and might be a potential therapeutic option for the treatment of LFJ OA causing LBP. (c) 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res