Effects of cyhalofop-butyl on the developmental toxicity and immunotoxicity in zebrafish (Danio rerio)
Effects of cyhalofop-butyl on the developmental toxicity and immunotoxicity in zebrafish (Danio rerio)
复制标题
氰氟草酯对斑马鱼（Danio rerio）发育毒性和免疫毒性的影响。
DOI：
10.1016/j.chemosphere.2020.127849
复制
发表时间：
2021-01-01
期刊：
影响因子：
8.8
通讯作者：
Lu, Huiqiang
中科院分区：
文献类型：
--
作者：
Cheng, Bo;Zou, Lufang;Lu, Huiqiang
氰氟草酯是一种广泛应用于农业的芳香族苯氧基丙酸类除草剂。但其对水生生物的免疫毒性研究未见报道。本文采用形态学、免疫学、细胞学、生物化学和分子生物学等方法，研究了氰氟草酯对斑马鱼的发育毒性和免疫毒性。结果表明，氰氟草酯染毒后，斑马鱼胚胎长度缩短，卵黄囊水肿，免疫细胞数量明显减少，出现炎症反应和免疫细胞凋亡。此外，我们还发现免疫相关基因和促凋亡基因的表达上调，JAK-STAT信号通路介导了氰氟草酯的免疫毒性。因此，本研究结果表明氰氟草酯对斑马鱼具有发育毒性和免疫毒性，为氰氟草酯暴露对水生生物的影响提供了新的研究内容。(C)2020爱思唯尔有限公司保留所有权利。
Cyhalofop-butyl is a kind of aromatic phenoxypropionic acid herbicide widely used in agriculture. However, studies on its immunotoxicity to aquatic organisms have not been reported. In this study paper, morphological, immunological, cytological, biochemical and molecular biology methods were used to study the effects of cyhalofop-butyl on the developmental toxicity and immunotoxicity in zebrafish. After cyhalofop-butyl exposed, the results showed that the zebrafish embryos had shorter length, yolk sac edema, significantly reduced number of immune cells, inflammatory response and immunocytes apoptosis. In addition, we found that the expression of immune-related genes and pro-apoptotic genes were up-regulated, and the JAK-STAT signaling pathway mediated the immunotoxicity induced by cyhalofop-butyl. Therefore, our results indicate that cyhalofop-butyl has developmental toxicity and immunotoxicity to zebrafish, and this study offer new contents for the effects of cyhalofop-butyl exposure on aquatic organisms. (C) 2020 Elsevier Ltd. All rights reserved.