Neuroelectronics and Biooptics: Closed-Loop Technologies in Neurological Disorders.
Neuroelectronics and Biooptics: Closed-Loop Technologies in Neurological Disorders.
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DOI：
10.1001/jamaneurol.2015.0608
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发表时间：
2015-07
期刊：
影响因子：
29
通讯作者：
Buzsáki G
中科院分区：
文献类型：
--
作者：
Krook-Magnuson E;Gelinas JN;Soltesz I;Buzsáki G
大脑植入装置不再是未来的想法。传统上，大多数神经系统疾病的治疗是基于随时间观察到的临床症状和诊断措施的变化来调整的。这些疗法通常是药理学或外科手术，需要连续或不可逆的治疗方案，不能迅速响应症状的波动或孤立的功能障碍发作。相比之下，闭环系统仅在需要时通过检测异常神经信号并利用瞬时反馈对其进行调制来提供干预。闭环系统已应用于几种神经系统疾病（最显著的是癫痫和运动障碍），但广泛使用受到概念和技术挑战的限制。在此，我们讨论了实验性闭环系统的进展如何有望改善神经系统疾病患者的临床获益。
Brain-implanted devices are no longer a futuristic idea. Traditionally, therapies for most neurological disorders are adjusted based on changes in clinical symptoms and diagnostic measures observed over time. These therapies are commonly pharmacological or surgical, requiring continuous or irreversible treatment regimens that cannot respond rapidly to fluctuations of symptoms or isolated episodes of dysfunction. In contrast, closed-loop systems provide intervention only when needed by detecting abnormal neurological signals and modulating them with instantaneous feedback. Closed-loop systems have been applied to several neurological conditions (most notably epilepsy and movement disorders), but widespread use is limited by conceptual and technical challenges. Herein, we discuss how advances in experimental closed-loop systems hold promise for improved clinical benefit in patients with neurological disorders.