A brief retraining regulates the persistence and lability of a long-term memory.
A brief retraining regulates the persistence and lability of a long-term memory.
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短暂的再训练可以调节长期记忆的持久性和不稳定性。
DOI：
10.1101/lm.1820010
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Susswein,AbrahamJ
中科院分区：
文献类型：
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作者：
Levitan,David;Twitto,Rachel;Levy,Roi;Lyons,LisaC;Susswein,AbrahamJ
在用不可食用的食物训练过加州龙蜥后，一种延长记忆持久性的经历也会使巩固的记忆对巩固阻滞剂变得敏感。长期（24小时）记忆由5分钟的训练开始，并依赖于训练后最初几个小时内的蛋白质合成。相比之下，更持久（48小时）的记忆取决于更长的训练时间和更晚的蛋白质合成。在训练后24小时，一个3分钟的不产生记忆的训练可以使一个只能持续24小时的记忆持续48小时。在48小时的记忆得到巩固后，3分钟的训练也使记忆对蛋白质合成抑制剂敏感。这些发现表明，使巩固的记忆对蛋白质合成阻滞剂变得敏感的功能可能是使记忆变得更加持久。
An experience extending the persistence of a memory after trainingAplysia californicawith inedible food also allows a consolidated memory to become sensitive to consolidation blockers. Long-term (24 h) memory is initiated by 5 min of training and is dependent on protein synthesis during the first few hours after training. By contrast, a more persistent (48 h) memory is dependent on a longer training session and on a later round of protein synthesis. When presented 24 h after training, a 3-min training that produces no memory alone can cause a memory that would have persisted for only 24 h to persist for 48 h. After a 48 h memory has been consolidated, 3 min of training also makes the memory sensitive to a protein-synthesis inhibitor. These findings suggest that a function of allowing a consolidated memory to become sensitive to blockers of protein synthesis may be to allow the memory to become more persistent.