Folic acid supplementation and fecundability: a Danish prospective cohort study
Folic acid supplementation and fecundability: a Danish prospective cohort study
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DOI：
10.1038/ejcn.2015.94
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发表时间：
2016-01-01
影响因子：
4.7
通讯作者：
Mikkelsen, E. M.
中科院分区：
文献类型：
--
作者：
Cueto, H. T.;Riis, A. H.;Mikkelsen, E. M.
背景/目的：围受孕期补充叶酸（FA）可降低神经管缺陷的风险，并与排卵功能有关。然而，只有两项研究将补充含有FA的多种维生素（MV）与妊娠率增加相关联。我们的目的是研究之间的关联FA补充剂（无论是通过单一FA片或通过MV）和fecundability.SUBJECTS/METHODS：3895丹麦妇女谁计划在2007年和2011年之间怀孕的前瞻性队列研究。我们使用比例概率回归模型估计了与FA补充（通过单一FA片剂或MV）相关的生育率（FR）和95%置信区间（CI），并对潜在的社会人口统计学、生殖和生活方式混杂因素进行了调整。在分层分析中，我们还估计FR与FA补充剂的妇女有规律和不规则的周期，分别为妇女短（= 30天），分别为95%CI：结果：FA补充剂与增加生育能力（FR = 1.15，95%CI = 1.06-1.25），与非使用。相对于不使用FA补充剂，使用FA补充剂的校正FR为1.35（95% CI = 1.12-1.65）和1.11（95%CI = 1.01-1.22），分别为不规则和规则周期的妇女，1.36（95% CI = 0.95-1.95），1.10（95% CI = 0.98-1.22）和1.24（95% CI = 1.10-1.41）（= 30天）。结论：补充FA与增加的繁殖力有关，这种关联在月经周期不规则的妇女和月经周期长短的妇女中似乎更强。
BACKGROUND/OBJECTIVES: Periconceptional folic acid (FA) supplementation reduces the risk of neural tube defects and has been associated with ovulatory function. However, only two studies have associated supplementation with multivitamins (MVs) that contained FA with increased pregnancy rates. We aimed to examine the association between FA supplementation (obtained either through single FA tablets or through MVs) and fecundability.SUBJECTS/METHODS: A prospective cohort study of 3895 Danish women who were planning a pregnancy between 2007 and 2011. We estimated fecundability ratios (FRs) and 95% confidence intervals (CIs) in relation to FA supplementation (either through single FA tablets or MV) using a proportional probabilities regression model, with adjustment for potential socio-demographic, reproductive and lifestyle confounders. In stratified analyses, we also estimated FR with 95% CI in relation to FA supplementation for women with regular and irregular cycles, respectively, and for women with short (= 30 days), respectively.RESULTS: FA supplementation was associated with increased fecundability (FR = 1.15, 95% CI = 1.06-1.25), compared with non-use. The adjusted FRs for FA supplement use relative to non-use were 1.35 (95% CI = 1.12-1.65) and 1.11 (95% CI = 1.01-1.22) for women with irregular and regular cycles, respectively, and 1.36 (95% CI = 0.95-1.95), 1.10 (95% CI = 0.98-1.22) and 1.24 (95% CI = 1.10-1.41) for women with short (= 30 days), respectively.CONCLUSIONS: FA supplementation was associated with increased fecundability, and this association appeared to be stronger among women with irregular cycles and among women with either short or long cycle length.