The Nuclear Pore Complex as a Flexible and Dynamic Gate.
The Nuclear Pore Complex as a Flexible and Dynamic Gate.
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DOI：
10.1016/j.cell.2016.01.034
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发表时间：
2016-03-10
期刊：
影响因子：
64.5
通讯作者：
Schwartz TU
中科院分区：
文献类型：
--
作者：
Knockenhauer KE;Schwartz TU
核孔复合物（NPCs）穿过核膜，是细胞核和细胞质之间分子交换的主要运输通道。将megadalton复合体分解为其最基本的组织元素，我们可以将NPC划分为支架组件，以及附着在其上的无序元素，这些元素在隔室之间产生选择性屏障。这些结构元素表现出灵活性，这可能有助于理解NPC的组装和功能。本文综述了NPC的研究现状，重点介绍了其结构和成分异质性的功能意义。
Nuclear pore complexes (NPCs) perforate the nuclear envelope and serve as the primary transport gates for molecular exchange between nucleus and cytoplasm. Stripping the megadalton complex down to its most essential organizational elements, one can divide the NPC into scaffold components, and the disordered elements attached to it that generate a selective barrier between compartments. These structural elements exhibit flexibility, which may hold a clue in understanding NPC assembly and function. Here we review the current status of NPC research with a focus on the functional implications of its structural and compositional heterogeneity.