[NiFe]-Hydrogenase maturation endopeptidase: structure and function.
[NiFe]-Hydrogenase maturation endopeptidase: structure and function.
复制标题
[NiFe]-氢化酶成熟内肽酶：结构和功能。
DOI：
10.1042/bst0330108
复制
发表时间：
2005
影响因子：
3.9
通讯作者：
A. Böck
中科院分区：
文献类型：
--
作者：
E. Theodoratou;R. Huber;A. Böck
氢化酶成熟内肽酶催化[NiFe]-氢化酶大亚基成熟的最终步骤。它们从亚基的前体中去除C-末端延伸，触发构象转换，导致金属中心的Fe和Ni原子通过半胱氨酸残基的硫醇盐桥接并关闭中心。本文综述了该蛋白的结构、底物特异性及其可能的反应机制。
Hydrogenase maturation endopeptidases catalyse the terminal step in the maturation of the large subunit of [NiFe]-hydrogenases. They remove a C-terminal extension from the precursor of the subunit, triggering a conformational switch that results in the bridging of the Fe and Ni atoms of the metal centre via the thiolate of a cysteine residue and in closure of the centre. This review summarizes what is known about the structure of the protein, its substrate specificity and its possible reaction mechanism.