New concepts in macrophage ontogeny in the adult neural retina
New concepts in macrophage ontogeny in the adult neural retina
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DOI：
10.1016/j.cellimm.2018.04.008
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发表时间：
2018-08-01
影响因子：
4.3
通讯作者：
Saban, Daniel R.
中科院分区：
文献类型：
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作者：
Saban, Daniel R.
据认为，负责视觉本身的神经元数量比其他四种感官的总和还要多。然而，与中枢神经系统其他部位相比，关于小胶质细胞（神经实质的巨噬细胞），视网膜很少受到关注。事实上，人们现在广泛认识到在理解大脑和脊髓的小胶质细胞个体发育和维持方面取得的重大进展，而在这方面对神经视网膜的关注却较少。当前的综述涵盖了稳态视网膜中成人小胶质细胞和血管周围巨噬细胞个体发育的主题概念，以及与中枢神经系统其他区域中这些巨噬细胞的相似之处。视网膜退行性疾病中招募的单核细胞及其后代单核细胞衍生的巨噬细胞的主题也纳入本综述。通篇强调了导致所涵盖理论的关键实验，以及尚未解决的知识差距。
The number of neurons dedicated to vision itself is thought to be greater than the sum of the four other senses combined. Yet, little attention has been payed to the retina as compared to elsewhere in the central nervous system with respect to microglia, the macrophages of the neural parenchyma. Indeed, major advancements in the understanding of microglial ontogeny and maintenance in brain and spinal cord are now widely appreciated, whereas less notice has been given to the neural retina in this regard. The current Review covers topical concepts on adult microglia and perivascular macrophage ontogenies in the steady state retina, as well as parallels made with these macrophages in other areas of the central nervous system. The subject of recruited monocytes and their descendant monocyte-derived macrophages in degenerative diseases of the retina is also integrated into this Review. Key experiments that have led to the theories covered are highlighted throughout, as are the knowledge gaps that remain unresolved.