An in vivo proton magnetic resonance spectroscopy study of schizophrenia patients.
An in vivo proton magnetic resonance spectroscopy study of schizophrenia patients.
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精神分裂症患者的体内质子磁共振波谱研究。
DOI：
10.1093/schbul/22.4.597
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发表时间：
1996
影响因子：
6.6
通讯作者：
Thompson,RT
中科院分区：
文献类型：
--
作者：
Stanley,JA;Williamson,PC;Drost,DJ;Rylett,RJ;Carr,TJ;Malla,A;Thompson,RT
应用短回波时间光谱技术，对不同病程的精神分裂症患者左背外侧前额叶1H代谢产物水平进行了活体检测。在早期发作和慢性阶段，观察到正常的N-乙酰天冬氨酸水平，这表明这些患者没有明显的神经元细胞损伤和/或损失。在体内测量的谷氨酸在第一次发作，drugnaive患者未能提供令人信服的证据参与的背外侧前额叶区的谷氨酸能系统。在急性用药和慢性患者中观察到谷氨酰胺水平的显著差异;然而，这些差异的解释需要进一步研究。
The level of the1H metabolites in the left dorsolateral prefrontal region of schizophrenia patients at different stages of illness were measured in vivo using a short echo time spectroscopy technique. During both the early onset and chronic stages, normalN-acetylaspartate levels were observed, which suggests that these patients had no significant neuronal cell damage and/or loss. The in vivo measurements of glutamate in the first-episode, drugnaive patients failed to provide convincing evidence for the involvement of the glutamatergic system in the dorsolateral prefrontal region. Significant differences in the glutamine levels were observed in the acutely medicated and chronic patients; however, the interpretation of these differences requires further study.