Highly Luminescent and Nontoxic Amine-Capped Nanoparticles from Porous Silicon: Synthesis and Their Use in Biomedical Imaging
Highly Luminescent and Nontoxic Amine-Capped Nanoparticles from Porous Silicon: Synthesis and Their Use in Biomedical Imaging
复制标题
DOI：
10.1021/am300642m
复制
发表时间：
2012-06-01
影响因子：
9.5
通讯作者：
Chao, Yimin
中科院分区：
文献类型：
--
作者：
Ahire, Jayshree H.;Wang, Qi;Chao, Yimin
以电化学腐蚀多孔硅为原料合成了稳定、发光性能好的氨基硅纳米粒子。通过FTIR、NMR和XPS研究证实了表面胺终止。通过透射电子显微镜（TEM）测量的平均直径为4.6 nm的晶体核心，这是在一个很好的协议，通过动态光散射（DLS）获得的大小。可以在不到4小时的时间内从大块硅片中获得干燥的胺封端产物。这代表了使用PSi的类似程序的显著改进，其中>10 h的时间是常见的。发现发射量子产率为约22%，并且纳米颗粒在宽pH范围（4-14）内表现出优异的稳定性。它们可以抵抗几周的老化。用MTT法测定，胺封端的SiNPs对HepG 2细胞没有显示出显著的细胞毒性作用。
Stable and brightly luminescent amine-terminated Si nanoparticles (SiNPs) have been synthesized from electrochemically etched porous silicon (PSi). The surface amine termination was confirmed by FTIR, NMR, and XPS studies. The mean diameter of the crystal core of 4.6 nm was measured by transmission electron microscopy (TEM), which is in a good agreement with the size obtained by dynamic light scattering (DLS). The dry, amine-terminated product can be obtained from bulk silicon wafers in less than 4 h. This represents a significant improvement over similar routines using PSi where times of >10 h are common. The emission quantum yield was found to be about 22% and the nanoparticles exhibited an exceptional stability over a wide pH range (4-14). They are resistant to aging over several weeks. The amine-terminated SiNPs showed no significant cytotoxic effects toward HepG2 cells, as assessed with MTT assays.