TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms.
TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms.
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TCF7L1 加速平滑肌细胞表型转换并加重腹主动脉瘤。
DOI：
10.1016/j.jacbts.2022.07.012
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发表时间：
2023-03
影响因子：
9.7
通讯作者：
Han, Yaling
中科院分区：
文献类型：
--
作者：
Wang, Jing;Tian, Xiaoxiang;Yan, Chenghui;Wu, Hanlin;Bu, Yuxin;Li, Jia;Liu, Dan;Han, Yaling
TCF 7 L1在AAA小鼠模型中上调。TCF 7 L1过表达增加Ang II诱导的AAAs形成。敲低TCF 7 L1可显著减少Ang II诱导的AAAs形成。TCF 7 L1过表达促进VSMC表型转化，而敲低抑制VSMC表型转化。TCF 7 L1过表达减弱了SRF的转录活性，已知SRF对VSMC表型稳定性具有重要调节作用。血管平滑肌细胞的表型转换是腹主动脉瘤（AAA）病理学的中心过程。我们发现，敲低TCF/LEF（T细胞因子/淋巴增强因子）转录因子家族成员TCF 7 L1（转录因子7样1）抑制血管平滑肌细胞分化。这项研究暗示了潜在的干预措施，以维持正常的，分化的平滑肌细胞状态，从而消除AAA的发病机制。此外，我们的研究提供了TCF 7 L1作为AAA生物标志物的潜在用途的见解。
TCF7L1 is upregulated in a mouse model of AAAs. TCF7L1 overexpression increases the formation of AAAs induced by Ang II. Knockdown TCF7L1 significantly reduces the formation of AAAs induced by Ang II. TCF7L1 overexpression promotes VSMC phenotypic transformation, while knocking down prevents VSMC phenotypic transformation in vitro. TCF7L1 overexpression attenuates the transcriptional activity of SRF, which is known to critically regulate VSMC phenotypic stability. Phenotypic switching of vascular smooth muscle cells is a central process in abdominal aortic aneurysm (AAA) pathology. We found that knockdown TCF7L1 (transcription factor 7-like 1), a member of the TCF/LEF (T cell factor/lymphoid enhancer factor) family of transcription factors, inhibits vascular smooth muscle cell differentiation. This study hints at potential interventions to maintain a normal, differentiated smooth muscle cell state, thereby eliminating the pathogenesis of AAA. In addition, our study provides insights into the potential use of TCF7L1 as a biomarker for AAA.
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5.6
作者：
Gurung R;Choong AM;Woo CC;Foo R;Sorokin V
通讯作者：
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DOI：
10.1016/j.ejvs.2010.09.011
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DOI：
10.1161/atvbaha.118.311727
发表时间：
2019-06-01
影响因子：
8.7
作者：
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通讯作者：
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