The tRNA-Derived Fragment-3017A Promotes Metastasis by Inhibiting NELL2 in Human Gastric Cancer.
The tRNA-Derived Fragment-3017A Promotes Metastasis by Inhibiting NELL2 in Human Gastric Cancer.
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tRNA 衍生片段 3017A 通过抑制 NELL2 促进人胃癌转移
DOI：
10.3389/fonc.2020.570916
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发表时间：
2020
影响因子：
4.7
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Tong L;Zhang W;Qu B;Zhang F;Wu Z;Shi J;Chen X;Song Y;Wang Z
转运RNA衍生片段（tRFs）是一类新的小非编码RNA（sncRNAs），来源于前体和成熟转运RNA的特异性切割。越来越多的近期证据表明，tRFs在多种癌症中常常出现异常。然而，tRFs在胃癌中的作用及其机制仍不清楚。在本研究中，我们发现tRF - 3017A（来源于tRNA - Val - TAC）在胃癌组织和细胞系中表达异常，并通过体外功能实验证实其对促进胃癌细胞侵袭和迁移的作用。临床病理数据分析显示，tRF - 3017A水平较高的患者与明显更高的淋巴结转移相关。机制研究表明，tRF - 3017A通过与Argonaute（AGO）蛋白形成RNA诱导沉默复合物（RISC）来调控肿瘤抑制基因NELL2。在本研究中，我们发现胃癌患者中tRF - 3017A水平较高与明显更高的淋巴结转移相关，并且tRF - 3017A可能通过沉默肿瘤抑制因子NELL2在促进胃癌细胞迁移和侵袭中发挥作用。
tRNA-derived fragments (tRFs) are a new classification of small non-coding RNAs (sncRNAs) derived from the specific cleavage of precursors and mature tRNAs. Accumulating recent evidence has shown that tRFs are frequently abnormal in several cancers. Nevertheless, the role of tRFs in gastric cancer and its mechanism remain unclear. In this study, we found abnormal expression of tRF-3017A (derived from tRNA-Val-TAC) in gastric cancer tissues and cell lines and confirmed its effect on promoting the invasion and migration of gastric cancer cells through functional experiments in vitro. Analysis of clinicopathologic data showed patients with higher tRF-3017A were associated with significantly higher lymph node metastasis. Mechanistic investigation implies that tRF-3017A regulates the tumor suppressor gene NELL2 through forming the RNA-induced silencing complex (RISC) with Argonaute (AGO) proteins. In this study, we found that higher tRF-3017A were associated with significantly higher lymph node metastasis in gastric cancer patients and the tRF-3017A may play a role in promoting the migration and invasion of gastric cancer cells by silencing tumor suppressor NELL2.
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DOI：
10.4137/bic.s20764
发表时间：
2014
期刊：
Biomarkers in cancer
影响因子：
--
作者：
Dhahbi JM;Spindler SR;Atamna H;Boffelli D;Martin DI
通讯作者：
Martin DI
影响因子：
3.7
作者：
Elbarbary RA;Takaku H;Uchiumi N;Tamiya H;Abe M;Takahashi M;Nishida H;Nashimoto M
通讯作者：
Nashimoto M
影响因子：
4.8
作者：
Falconi, Maurizio;Giangrossi, Mara;Amici, Augusto
通讯作者：
Amici, Augusto
影响因子：
28.4
作者：
Global Burden of Disease Cancer Collaboration;Fitzmaurice C;Allen C;Barber RM;Barregard L;Bhutta ZA;Brenner H;Dicker DJ;Chimed-Orchir O;Dandona R;Dandona L;Fleming T;Forouzanfar MH;Hancock J;Hay RJ;Hunter-Merrill R;Huynh C;Hosgood HD;Johnson CO;Jonas JB;Khubchandani J;Kumar GA;Kutz M;Lan Q;Larson HJ;Liang X;Lim SS;Lopez AD;MacIntyre MF;Marczak L;Marquez N;Mokdad AH;Pinho C;Pourmalek F;Salomon JA;Sanabria JR;Sandar L;Sartorius B;Schwartz SM;Shackelford KA;Shibuya K;Stanaway J;Steiner C;Sun J;Takahashi K;Vollset SE;Vos T;Wagner JA;Wang H;Westerman R;Zeeb H;Zoeckler L;Abd-Allah F;Ahmed MB;Alabed S;Alam NK;Aldhahri SF;Alem G;Alemayohu MA;Ali R;Al-Raddadi R;Amare A;Amoako Y;Artaman A;Asayesh H;Atnafu N;Awasthi A;Saleem HB;Barac A;Bedi N;Bensenor I;Berhane A;Bernabé E;Betsu B;Binagwaho A;Boneya D;Campos-Nonato I;Castañeda-Orjuela C;Catalá-López F;Chiang P;Chibueze C;Chitheer A;Choi JY;Cowie B;Damtew S;das Neves J;Dey S;Dharmaratne S;Dhillon P;Ding E;Driscoll T;Ekwueme D;Endries AY;Farvid M;Farzadfar F;Fernandes J;Fischer F;G/Hiwot TT;Gebru A;Gopalani S;Hailu A;Horino M;Horita N;Husseini A;Huybrechts I;Inoue M;Islami F;Jakovljevic M;James S;Javanbakht M;Jee SH;Kasaeian A;Kedir MS;Khader YS;Khang YH;Kim D;Leigh J;Linn S;Lunevicius R;El Razek HMA;Malekzadeh R;Malta DC;Marcenes W;Markos D;Melaku YA;Meles KG;Mendoza W;Mengiste DT;Meretoja TJ;Miller TR;Mohammad KA;Mohammadi A;Mohammed S;Moradi-Lakeh M;Nagel G;Nand D;Le Nguyen Q;Nolte S;Ogbo FA;Oladimeji KE;Oren E;Pa M;Park EK;Pereira DM;Plass D;Qorbani M;Radfar A;Rafay A;Rahman M;Rana SM;Søreide K;Satpathy M;Sawhney M;Sepanlou SG;Shaikh MA;She J;Shiue I;Shore HR;Shrime MG;So S;Soneji S;Stathopoulou V;Stroumpoulis K;Sufiyan MB;Sykes BL;Tabarés-Seisdedos R;Tadese F;Tedla BA;Tessema GA;Thakur JS;Tran BX;Ukwaja KN;Uzochukwu BSC;Vlassov VV;Weiderpass E;Wubshet Terefe M;Yebyo HG;Yimam HH;Yonemoto N;Younis MZ;Yu C;Zaidi Z;Zaki MES;Zenebe ZM;Murray CJL;Naghavi M
通讯作者：
Naghavi M
DOI：
10.1073/pnas.1206761110
发表时间：
2013-01-22
影响因子：
11.1
作者：
Maute, Roy L.;Schneider, Christof;Dalla-Favera, Riccardo
通讯作者：
Dalla-Favera, Riccardo