Potent and tumor specific: arming bacteria with therapeutic proteins.
Potent and tumor specific: arming bacteria with therapeutic proteins.
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DOI：
10.4155/tde.14.113
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发表时间：
2015-03
影响因子：
4.2
通讯作者：
Forbes NS
中科院分区：
文献类型：
--
作者：
Van Dessel N;Swofford CA;Forbes NS
细菌是癌症靶向治疗的完美载体。传统化疗受到被动扩散的限制，全身给药会导致严重的副作用。细菌可以通过向肿瘤特异性递送治疗蛋白来克服这些障碍。细菌经过修饰后可以产生直接杀死细胞的蛋白质，通过信号通路诱导细胞凋亡，并刺激免疫系统。这三种细菌治疗模式均已被证明可以减少动物模型中的肿瘤生长。细菌还被设计用于将无毒前药转化为活性治疗化合物。基因操作的简便性使得能够创建释放许多新蛋白质药物的细菌阵列。这种多功能性将允许针对多种癌症途径，并将建立个体化癌症医学平台。
Bacteria are perfect vessels for targeted cancer therapy. Conventional chemotherapy is limited by passive diffusion, and systemic administration causes severe side effects. Bacteria can overcome these obstacles by delivering therapeutic proteins specifically to tumors. Bacteria have been modified to produce proteins that directly kill cells, induce apoptosis via signaling pathways, and stimulate the immune system. These three modes of bacterial treatment have all been shown to reduce tumor growth in animal models. Bacteria have also been designed to convert nontoxic prodrugs to active therapeutic compounds. The ease of genetic manipulation enables creation of arrays of bacteria that release many new protein drugs. This versatility will allow targeting of multiple cancer pathways and will establish a platform for individualized cancer medicine.