Impact of female age and nulligravidity on fecundity in an older reproductive age cohort.
Impact of female age and nulligravidity on fecundity in an older reproductive age cohort.
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DOI：
10.1016/j.fertnstert.2016.02.028
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发表时间：
2016-06
影响因子：
6.7
通讯作者：
Jukic AM
中科院分区：
文献类型：
--
作者：
Steiner AZ;Jukic AM
To provide female age-related estimates of fecundity and incidence of infertility by history of prior pregnancy among women 30 to 44 years of age. Prospective, time-to-pregnancy cohort study Community-based cohort Women, between 30 and 44 years of age, attempting to conceive for three or fewer months, and no known history of infertility, polycystic ovarian syndrome, or endometriosis None Fecundability and incidence of infertility Compared to women ages 30–31, fecundability was reduced by 14% in women 34–35 years of age (Fecundability Ratio (FR) 0.86, 95% CI: 0.68–1.08), 19% in women 36–37 years of age (FR 0.81,95% CI: 0.60–1.08, 30% in women 38–39 (FR 0.70, 95% CI: 0.48–1.01), 53% in women 40–41 (FR 0.47, 95% CI 0.28–0.78) and 59% in women 42–44 (FR 0.39, 95% CI 0.16–0.93). Fecundability did not differ between women ages 30–31 and women ages 32–33 years. In general, fecundability and cumulative probability of pregnancy was lower for women, who had never had a prior pregnancy. Women experience a significant reduction in fecundity and increase in the probability of infertility in their late thirties. At any age over 30, women who have never conceived before have a lower probability of achieving a pregnancy.
