Connective tissue growth factor: a novel regulator of mucosal repair and fibrosis in inflammatory bowel disease?
Connective tissue growth factor: a novel regulator of mucosal repair and fibrosis in inflammatory bowel disease?
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DOI：
10.1016/s1357-2725(98)00046-6
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发表时间：
1998-08-01
影响因子：
4
通讯作者：
Werner, S
中科院分区：
文献类型：
--
作者：
Dammeier, J;Brauchle, M;Werner, S
炎症性肠病（IBD）是一种多因素疾病，其特征是肠道上皮和底层间质的严重损伤。由于结缔组织生长因子 (CTGF) 对成纤维细胞增殖和结缔组织沉积的强大作用，我们推测这种有丝分裂原在 IBD 中可能发挥作用。在这里，我们证明了患有两种形式的 IBD（克罗恩病和溃疡性结肠炎）患者的手术标本中 CTGF mRNA 的表达显着增加。在大多数标本中，CTGF mRNA 水平与炎症程度相关，通过邻近组织样本的组织学分析和促炎细胞因子白细胞介素 1 β 的表达分析进行评估。然而，以严重纤维化为特征的轻微炎症区域也显示出高水平的 CTGF mRNA。转化生长因子β-1（TGF-β1）是迄今为止唯一已知的CTGF诱导剂，以及CTGF靶基因胶原蛋白Iα1、纤连蛋白和整合素α5的表达与CTGF的表达具有很强的相关性。这些数据表明CTGF在IBD粘膜损伤的修复以及导致纤维化和狭窄的细胞外基质异常沉积中发挥着重要作用，纤维化和狭窄是IBD的主要并发症之一。 IBD，尤其是克罗恩病。 (C) 1998 Elsevier Science Ltd. 保留所有权利。
Inflammatory bowel disease (IBD) is a multifactorial disorder which is characterized by massive damage of the epithelium and the underlying mesenchyme of the intestine. Due to the potent effect of connective tissue growth factor (CTGF) on fibroblast proliferation and connective tissue deposition we speculated about a possible role of this mitogen in IBD. Here we demonstrate a strikingly increased expression of CTGF mRNA in surgical specimens of patients suffering from two forms of IBD, Crohn's disease and ulcerative colitis. In most specimens, the levels of CTGF mRNA correlated with the degree of inflammation as assessed by histological analysis of adjacent tissue samples and by expression analysis of the pro-inflammatory cytokine interleukin-1 beta. However, areas of little inflammation which were characterized by severe fibrosis also revealed high levels of CTGF mRNA. Expression of transforming growth factor beta-1 (TGF-beta 1), the only known inducer of CTGF so far, as well as of the CTGF target genes collagen I alpha 1, fibronectin and integrin alpha 5 revealed a strong correlation with the expression of CTGF, These data suggest a prominent role of CTGF in the repair of mucosal injury in IBD and in the aberrant deposition of extracellular matrix leading to fibrosis and stenosis, one major complication in IBD, especially in Crohn's disease. (C) 1998 Elsevier Science Ltd. All rights reserved.