Chrono-neuroendocrine markers of the aging brain
Chrono-neuroendocrine markers of the aging brain
复制标题
衰老大脑的时间神经内分泌标志物
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
S. Solerte
中科院分区：
文献类型：
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作者：
E. Ferrari;F. Magri;M. Locatelli;G. Balza;T. Nescis;C. Battegazzore;G. Cuzzoni;M. Fioravanti;S. Solerte
对衰老过程中神经内分泌变化的研究可以提供有关中枢神经系统功能的信息，并解释衰老机体可塑性受损的原因。在16名老年妇女和14名年轻的控制，血浆褪黑激素，生长激素，催乳素，促肾上腺皮质激素和皮质醇，口腔温度的昼夜节律进行了研究。还在DXM给药（23：00口服1 mg）后评价了血浆皮质醇昼夜节律。在老年受试者中评价的所有生物周期功能的昼夜节律特征明显变平，与年轻对照组相比，老年受试者中GH、PRL和褪黑激素的激素夜间分泌受损明显。血浆ACTH水平在整个24小时周期中显着高于老年人比年轻的受试者。与年轻对照组相比，老年受试者的皮质醇昼夜节律曲线在晚上和夜间显示出显著较高的值;皮质醇最低值与年龄显著相关。老年组对DXM抑制的敏感性降低。夜间褪黑素分泌的选择性障碍和下丘脑-垂体-肾上腺（HPA）对类固醇反馈的敏感性降低可能被认为是脑老化的标志。生理性衰老的神经内分泌改变可能归因于CNS中发生的结构和神经化学变化。
The study of the neuroendocrine changes occurring in aging may give information about the CNS functions, and also explain the impaired plasticity of the aged organism. In 16 elderly women and in 14 young controls, the circadian rhythms of plasma melatonin, GH, PRL, ACTH and cortisol, and of oral temperature were simultaneously studied. The plasma cortisol circadian rhythm was also evaluated after DXM administration (1 mg orally at 23:00). The circadian profile of all the bioperiodic functions evaluated was clearly flattened in elderly subjects, and an impairment of the hormonal nocturnal secretion of GH, PRL and melatonin was apparent in elderly subjects when compared to young controls. The plasma ACTH levels throughout the 24-hour cycle were significantly higher in elderly than in young subjects. The cortisol circadian profile exhibited significantly higher values in the evening- and night-time in elderly subjects, compared to young controls; the cortisol nadir values were significantly age-related. A reduction of the sensitivity to DXM inhibition occurred in the elderly group. Both the selective impairment of nocturnal melatonin secretion, and the reduction of hypothalamo-pituitary-adrenal (HPA) sensitivity to steroid feedback might be considered as markers of aging brain. The neuroendocrine alterations of physiological aging may be ascribable to both the structural and neurochemical changes occurring in the CNS.
影响因子：
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作者：
B. Carroll;M. Feinberg;J. Greden;J. Tarika;A. Albala;R. Haskett;Norman McI. James;Z. Kronfol;N. Lohr;M. Steiner;Jean Paul de Vigne;E. Young
通讯作者：
B. Carroll;M. Feinberg;J. Greden;J. Tarika;A. Albala;R. Haskett;Norman McI. James;Z. Kronfol;N. Lohr;M. Steiner;Jean Paul de Vigne;E. Young
老年男性的神经内分泌节律和睡眠。
DOI：
10.1152/ajpendo.1991.260.4.e651
发表时间：
1991
期刊：
The American journal of physiology
影响因子：
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作者：
vanCoevorden,A;Mockel,J;Laurent,E;Kerkhofs,M;L'Hermite-Balériaux,M;Decoster,C;Nève,P;VanCauter,E
通讯作者：
VanCauter,E