Neonatally bulbectomized rats with new olfactory-neocortical connections are anosmic
Neonatally bulbectomized rats with new olfactory-neocortical connections are anosmic
复制标题
具有新的嗅觉-新皮质连接的新生球切除大鼠嗅觉丧失
DOI：
10.1016/0304-3940(84)90046-6
复制
发表时间：
1984
影响因子：
2.5
通讯作者：
B. Slotnick
中科院分区：
文献类型：
--
作者：
A. Butler;P. Graziadei;G. Graziadei;B. Slotnick
老鼠在新生儿时被移除了一个嗅球，在成年大鼠上被移除了第二个嗅球，并进行了音光辨别和气味检测任务的测试。在新生儿手术侧，重建的嗅觉受体细胞轴突穿透额叶新皮质或前嗅核的部分，并形成肾小球样结构。在成人手术侧，有广泛的疤痕形成，阻止了向内生长的感觉轴突接触大脑。所有实验动物都获得了音光辨别能力，但没有表现出任何气味检测的证据。这些结果表明，终止于额叶新皮质或前嗅核的重建嗅觉投射不支持嗅觉。
Rats with one olfactory bulb removed when neonates and the second bulb removed when adults were tested on tone-light discrimination and odor detection tasks. On the neonatally operated side reconstituted olfactory receptor cell axons penetrated the frontal neocortex or portions of the anterior olfactory nucleus, and formed glomerular-like structures. On the adult operated side there was extensive scar formation which prevented in-growing sensory axons from contacting the brain. All experimental animals acquired the tone-light discrimination but failed to show any evidence of odor detection. These results indicate that reconstituted olfactory projections which terminate in the frontal neocortex or anterior olfactory nucleus do not support olfaction.