LncRNA NKILA correlates with the malignant status and serves as a tumor-suppressive role in rectal cancer
LncRNA NKILA correlates with the malignant status and serves as a tumor-suppressive role in rectal cancer
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DOI：
10.1002/jcb.27300
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发表时间：
2018-12-01
影响因子：
4
通讯作者：
Dong, Ming
中科院分区：
文献类型：
--
作者：
Tao, Fei;Xu, Yongpan;Dong, Ming
NF-kappa B相互作用lncRNA （NKILA）已被发现在多种人类癌症中发挥肿瘤抑制作用。然而，NKILA在直肠癌中的作用尚不清楚。本研究的目的是探讨NKILA在直肠癌中的临床价值和生物学功能。估计直肠癌患者NKILA表达与包括预后在内的临床变量之间的关系。通过NKILA在直肠癌细胞中的功能获得性研究，评估NKILA对直肠癌细胞增殖、迁移、侵袭及NF-kappa B信号通路的影响。结果提示NKILA在直肠癌组织和细胞中表达降低，且与临床分期、T分型、N分型、M分型相关。NKILA低表达是直肠癌患者预后不良的独立因素。nkila通过抑制nf - κ B信号传导抑制直肠癌细胞增殖、迁移和侵袭。综上所述，NKILA在直肠癌中是一种抗原性lncRNA。
NF-kappa B interacting lncRNA (NKILA) has been found to function as a tumor-suppressive role in various human cancers. However, the role of NKILA in rectal cancer is still unknown. The objective of this study is to investigate the clinical value and biological function of NKILA in rectal cancer. The association between NKILA expression and clinical variables including prognosis was estimated in rectal cancer patients. The gain-of-function study of NKILA in rectal cancer cell was conducted to evaluate the effect of NKILA on cell proliferation, migration, invasion, and NF-kappa B signaling pathway. The results suggested NKILA expression was decreased in rectal cancer tissues and cells, and correlated with clinical stage, T classification, N classification and M classification. NKILA low-expression was an independent poor prognostic factor in rectal cancer patients. NKILA-inhibited rectal cancer cell proliferation, migration, and invasion via suppressing NF-kappa B signaling. In conclusion, NKILA serves as an antioncogenic lncRNA in rectal cancer.